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β-glucan metabolic and immunomodulatory properties and potential for clinical application
(MDPI, 2020-12-10)
β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties. β-glucans have metabolic and gastro-intestinal effects, ...
Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions
(Elsevier, 2022-02-25)
Acute respiratory distress syndrome (ARDS) is the most common form of acute severe hypoxemic respiratory failure in the critically ill with a hospital mortality of 40%. Alveolar inflammation is one of the hallmarks for ...
A bilayer vaginal tablet for the localized delivery of disulfiram and 5-fluorouracil to the cervix
(MDPI, 2020-12-06)
This study was performed to develop an adjuvant therapy in the form of a self-administered
vaginal tablet regimen for the localized delivery of chemotherapeutic drugs. This therapy will help to
reduce relapse by eradicating ...
Purified β‐glucans from the Shiitake mushroom ameliorates antibiotic‐resistant Klebsiella pneumoniae‐induced pulmonary sepsis
(Society for Applied Microbiology, 2020-07-24)
Bacterial infection remains the main cause of acute respiratory distress syndrome and is a leading cause of death and disability in critically ill patients. Here we report on the use of purified β‐glucan (lentinan) extracts ...
Development of a low-temperature extrusion process for production of GRAS bioactive-polymer loaded compounds for targeting antimicrobial-resistant (AMR) bacteria
(Elsevier, 2021-08-10)
Antimicrobial resistance (AMR) is recognised globally as one of the greatest threats to human and animal health; thus, discovery of alternative antibacterial agents to address AMR is a priority challenge. This study ...
β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects — Implications for coronavirus disease (COVID-19) immunotherapies.
(Elsevier, 2020-05-11)
Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute respiratory distress syndrome (ARDS) and death. ...
Synergy assessment of four antimicrobial bioactive compounds for the combinational treatment of bacterial pathogens
(MDPI, 2023-08-07)
Antimicrobial resistance (AMR) has become a topic of great concern in recent years, with
much effort being committed to developing alternative treatments for resistant bacterial pathogens.
Drug combinational therapies ...