Browsing Articles - Bioscience Research Institute (BRI) by Author "Major, Ian"
Now showing items 1-7 of 7
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A bilayer vaginal tablet for the localized delivery of disulfiram and 5-fluorouracil to the cervix
Abidin, Ismin Zainol; Rezoagli, Emanuele; Simonassi-Paiva, Bianca; Fehrenbach, Gustavo Waltzer; Masterson, Kevin; Pogue, Robert; Cao, Zhi; Rowan, Neil; Murphy, Emma J.; Major, Ian (MDPI, 2020-12-06)This study was performed to develop an adjuvant therapy in the form of a self-administered vaginal tablet regimen for the localized delivery of chemotherapeutic drugs. This therapy will help to reduce relapse by eradicating ... -
Development of a low-temperature extrusion process for production of GRAS bioactive-polymer loaded compounds for targeting antimicrobial-resistant (AMR) bacteria
Masterson, Kevin; Meade, Elaine; Garvey, Mary; Lynch, Mark; Major, Ian; Rowan, Neil J. (Elsevier, 2021-08-10)Antimicrobial resistance (AMR) is recognised globally as one of the greatest threats to human and animal health; thus, discovery of alternative antibacterial agents to address AMR is a priority challenge. This study ... -
Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions
Murphy, Emma J.; Rezoagli, Emanuele; Pogue, Robert; Simonassi-Paiva, Bianca; Abidin, Ismin Izwani Zainol; Fehrenbach, Gustavo Waltzer; O'Neil, Emer; Major, Ian; Laffey, John G.; Rowan, Neil J. (Elsevier, 2022-02-25)Acute respiratory distress syndrome (ARDS) is the most common form of acute severe hypoxemic respiratory failure in the critically ill with a hospital mortality of 40%. Alveolar inflammation is one of the hallmarks for ... -
Purified β‐glucans from the Shiitake mushroom ameliorates antibiotic‐resistant Klebsiella pneumoniae‐induced pulmonary sepsis
Masterson, Claire H.; Murphy, Emma J.; Gonzalez, H.; Major, Ian; McCarthy, S.D.; O'Toole, D.; Laffey, John G.; Rowan, Neil J. (Society for Applied Microbiology, 2020-07-24)Bacterial infection remains the main cause of acute respiratory distress syndrome and is a leading cause of death and disability in critically ill patients. Here we report on the use of purified β‐glucan (lentinan) extracts ... -
Synergy assessment of four antimicrobial bioactive compounds for the combinational treatment of bacterial pathogens
Masterson, Kevin; Major, Ian; Lynch, Mark; Rowan, Neil (MDPI, 2023-08-07)Antimicrobial resistance (AMR) has become a topic of great concern in recent years, with much effort being committed to developing alternative treatments for resistant bacterial pathogens. Drug combinational therapies ... -
β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects — Implications for coronavirus disease (COVID-19) immunotherapies.
Murpyhy, Emma J.; Masterson, Claire; Rezoagli, Emanuele; O'Toole, Daniel; Major, Ian; Stack, Gary D.; Lynch, Mark; Laffey, John G.; Rowan, Neil J. (Elsevier, 2020-05-11)Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute respiratory distress syndrome (ARDS) and death. ... -
β-glucan metabolic and immunomodulatory properties and potential for clinical application
Murphy, Emma J.; Rezoagli, Emanuele; Major, Ian; Rowan, Neil J.; Laffey, John G. (MDPI, 2020-12-10)β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties. β-glucans have metabolic and gastro-intestinal effects, ...