Search
Now showing items 11-18 of 18
Smart hydrogels: therapeutic advancements in hydrogel technology for smart drug delivery applications.
(Wiley, 2015-12)
Hydrogels are a fusion of solid and liquid phases which closely mimic biological tissue. As such they have enormous potential for drug delivery systems as they are biocompatible and may be tailored to specific applications. ...
The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system.
(IOP Science, 2019-06-05)
Although freeze-thaw mechanism for producing crosslinked hydrogels is relatively easy and simple, it
lacks sufficient integrity and support leading to modifications on its three-dimensional polymeric
network arrangement ...
Preparation of a novel freeze thawed poly (vinly alcohol) composite hydrogel for drug delivery applications
(Elsevier, 2007-09)
Poly(vinyl alcohol) (PVA) is a water-soluble, biocompatible and biodegradable polymer, which has been widely applied in biomedical fields. In this paper, novel physically cross-linked hydrogels composed of PVA and comprising ...
"My heart, your heart"; hot melt enteric targeted therapeutic delivery platform: enhancing drug solubility through advanced polymer extruded drug delivery system
(Athlone Institute of Technology, 2020-06)
Cardiovascular diseases (CVDs) are the number 1 cause
of death globally. Fenofibrate has been shown an
excellent treating effect on CVDs. However, Fenofibrate
is a neutral, lipophilic compound that is practically
insoluble ...
Synthesis and characterisation of novel temperature and pH sensitive physically crosslinked poly(N-vinylcaprolactam-co-itaconic acid) hydrogels for drug delivery.
(MDPI, 2019-08-29)
Previous studies involving poly N-vinylcaprolactam (PNVCL) and itaconic acid (IA) have synthesised the hydrogels with the presence of a solvent and a crosslinker, producing chemically crosslinked hydrogel systems. In this ...
Development of novel monolithic matrices for drug delivery using conventional and non-conventional polymer processing technologies.
(2007)
The aim of this study was to produce a range of polymer based monolithic matrices
for controlled oral drug delivery using conventional polymer processing equipment. Poly
(ethylene oxide) (PEO) was chosen as the primary ...
Novel polyvinyl-alcohol microsphere for everolimus delivery for subependymal cell astrocytoma
(Elsevier, 2023-02-02)
Everolimus (EVR) has demonstrated efficacy in treating subependymal giant cell astrocytoma (SEGA) and other
tuberous sclerosis (TSC) manifestations. Oral use of EVR is associated with low bioavailability and systemic
toxicities ...
Enhancing drug solubility through advanced polymer extruded shellac-based matrix drug delivery systems
(Technological University of the Shannon: Midlands Midwest, 2022-09)
The main objective of this study is to enhance the solubility of the model drug
fenofibrate, by forming amorphous solid dispersions using a hot melt extrusion process.
Hot melt extrusion offers an efficient way of ...