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Extended release of proteins following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications.
(Elsevier, 2018-03)
Highlights:
Biocompatible, mechanically robust scaffold with an appropriate stability for bone healing when used with fixation device.
Proteins can be covalently attached to the scaffold.
Proteins are released for an ...
Platelet-rich plasma, Hydroxyapatite, and Chitosan in the bone and cartilaginous regeneration of femoral trochlea in rabbits: clinical, radiographic, and histomorphometric evaluations.
(Hindawi, 2018-06)
The aim of this study was to evaluate the trochlear bone and cartilaginous regeneration of rabbits using the association of PRP,
chitosan, and hydroxyapatite. Hole was made in rabbit troches, one hole in each animal ...
The osteoinduction of C2C12 myoblast cell-line treated with growth factor-incorporated biocomposites
(TUS Midlands Midwest, 2022)
Bone regeneration scaffold serves as an alternative treatment to critical bone defects,
substituting the traditional gold standard autologous bone grafting. A number of
biomaterials and osteogenic growth factors are of ...
Preclinical assessment of biomimetic and bioactive bone regeneration scaffold in femoral condyle defect of Sprague Dawley rats.
(Athlone Institute of Technology, 2020)
A fabricated biomimetic bone scaffold, incorporating osteogenic factors, presents a promising alternative to traditional autologous and
allogeneic bone fracture treatments. Here, the principles of biology and engineering ...
Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model.
(Wiley Online Library, 2019-08-08)
Scaffolds are models designed to aid the interaction between cells and extracellular bone matrix, providing structural support for newly formed bone tissue. In this work, wollastonite with β‐TCP porous ceramic scaffolds ...
Photopolymerization for filling porous ceramic matrix: improvement of mechanical properties and drug delivering behaviour.
(Wiley, 2019-04)
This work presents the photopolymerisation of composite scaffolds where a prefabricated ceramic scaffold was impregnated with poly(ethylene) glycol dimethacrylate (PEGDMA) macromonomer solution. The PEGDMA solution penetrates ...
Development of a new bone scaffold for the treatment of large bone defects
(Athlone Institute of Technology, 2020-06)
Large bone defects
are typically caused by incidents
such
as fractures, diseases, trauma or surgeries. Worldwide more that 3/5 million bone grafts (either autografts or allografts) are performed each year.
Bioactive composites fabricated by freezing-thawing method for bone regeneration applications.
(Wiley, 2016-04)
Hydrogels are widely used for controlled delivery of therapeutic agents. However, hydrogels lack bioactivity to encourage bone formation and mechanical integrity. Moreover, chemically crosslinked hydrogels exhibit cytotoxic ...
Enhancement of scaffold in vivo biodegradability for bone regeneration using P28 peptide formulations
(MDPI, 2023-06-13)
The field of bone tissue engineering has shown a great variety of bone graft substitute
materials under development to date, with the aim to reconstruct new bone tissue while maintaining
characteristics close to the ...
The optimisation of biomimetic scaffold fabrication for the controlled release of Osteogenic factors for bone tissue regeneration
(Technological University of the Shannon: Midlands Midwest, 2023-08)
Bone tissue defect is a rising global concern and is one of the leading causes of morbidity
and disability in patients. Bone regeneration treatments that demonstrate all key
characteristics for successful bone healing: ...