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    On the possibility of replacement of calcium carbonate by a high-performance, economically viable filler in polyethylene composites 

    Hesabi, Mohammadnabi; Brennan, Shane; Boulard, Quentin; Le Blanc, Francois; Major, Ian (Sage, 2021-07-14)
    Calcium carbonate (CaCO3) is frequently added to polyethylene (PE) as a filler to reduce costs. An alternative to CaCO3, calcium fluoride (CaF2) was proposed in this research. PE/CaCO3 and PE/CaF2 composites in a wide ...
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    Polymer based additive manufacturing historical developments, process types and material considerations. 

    Pollack, Steven; Venkatesh, Chaitra; Neff, Martin; Hu, Guang; Fuenmayor, Evert; Lyons, John G.; Major, Ian; Devine, Declan M. (Springer Nature, 2019)
    3D printing is a manufacturing technique where parts are built in a layer-by-layer fashion. The earliest embodiments were based on generating successive layers of solidified materials at the air liquid interface through ...
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    A bilayer vaginal tablet for the localized delivery of disulfiram and 5-fluorouracil to the cervix 

    Abidin, Ismin Zainol; Rezoagli, Emanuele; Simonassi-Paiva, Bianca; Fehrenbach, Gustavo Waltzer; Masterson, Kevin; Pogue, Robert; Cao, Zhi; Rowan, Neil; Murphy, Emma J.; Major, Ian (MDPI, 2020-12-06)
    This study was performed to develop an adjuvant therapy in the form of a self-administered vaginal tablet regimen for the localized delivery of chemotherapeutic drugs. This therapy will help to reduce relapse by eradicating ...
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    Hyaluronic acid: a review of the drug delivery capabilities of this naturally occurring polysaccharide 

    Buckley, Ciara; Murphy, Emma J.; Montgomery, Therese R.; Major, Ian (MDPI, 2022-08-23)
    The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially ...
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    Production and testing of the flat faced tablets via overprinting of injection moulded tablet bases 

    Xu, Han; Major, Ian; Fuenmayor, Evert (Technological University of the Shannon Midlands Midwest, 2022)
    Conventional drug production assures the merits of maintaining unit dosage form accuracy, stable dose and invariability among the batches. It also has a shortcoming that cannot make personalised medicine that could target ...
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    Purified β‐glucans from the Shiitake mushroom ameliorates antibiotic‐resistant Klebsiella pneumoniae‐induced pulmonary sepsis 

    Masterson, Claire H.; Murphy, Emma J.; Gonzalez, H.; Major, Ian; McCarthy, S.D.; O'Toole, D.; Laffey, John G.; Rowan, Neil J. (Society for Applied Microbiology, 2020-07-24)
    Bacterial infection remains the main cause of acute respiratory distress syndrome and is a leading cause of death and disability in critically ill patients. Here we report on the use of purified β‐glucan (lentinan) extracts ...
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    Development of a low-temperature extrusion process for production of GRAS bioactive-polymer loaded compounds for targeting antimicrobial-resistant (AMR) bacteria 

    Masterson, Kevin; Meade, Elaine; Garvey, Mary; Lynch, Mark; Major, Ian; Rowan, Neil J. (Elsevier, 2021-08-10)
    Antimicrobial resistance (AMR) is recognised globally as one of the greatest threats to human and animal health; thus, discovery of alternative antibacterial agents to address AMR is a priority challenge. This study ...
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    Vaginal drug delivery for the localised treatment of cervical cancer. 

    Major, Ian; McConville, Christopher (Springer, 2017-06-08)
    Cervical cancer is usually treated by surgery, with the more advanced cancers requiring adjuvant chemotherapy or radiotherapy. The location of the cervix makes it easily accessible through the vagina for the localised ...
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    Additive manufacturing of PLA/HNT nanocomposites for biomedical applications 

    Venkatesh, Chaitra; Fuenmayor, Evert; Doran, Patrick; Major, Ian (Elsevier, 2019)
    Additive manufacturing has been of great interest of research in various applications due to their ease in processability, cost effectiveness and adaptability. In this study Poly Lactic Acid (PLA) was used as the base ...
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    Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel 

    Boyd, Peter; Fetherston, Susan M.; McCoy, Clare F.; Major, Ian; Murphy, Diarmaid J.; Kumar, Sandeep; Holt, Jonathon; Brimer, Andrew; Blanda, Wendy; Devlin, Brid; Malcolm, R. Karl (Elsevier, 2016-09-10)
    A matrix-type silicone elastomer vaginal ring providing 28-day continuous release of dapivirine (DPV) ⿿ a lead candidate human immunodeficiency virus type 1 (HIV-1) microbicide compound ⿿ has recently demonstrated moderate ...
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    Major, Ian (37)
    Devine, Declan M. (11)Fuenmayor, Evert (11)Lyons, John G. (10)McConville, Christopher (8)Murphy, Emma J. (8)Cao, Zhi (7)Rezoagli, Emanuele (7)Rowan, Neil J. (6)Doran, Patrick (4)... View MoreSubjectMaterials Research Institute AIT (11)3D printing (10)Bioscience Research Institute AIT (7)Materials Research Institute (7)Injection molding (5)Additive manufacturing (4)Cervical cancer (4)Hot-melt extrusion (4)Materials Research Institute - AIT (4)Vaginal drug delivery (3)... View MoreDate Issued2020 (9)2019 (8)2022 (5)2021 (4)2016 (3)2018 (3)2017 (2)2014 (1)2015 (1)2023 (1)Has File(s)
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