Browsing Technological University of the Shannon: Midlands Midwest by Author "Nugent, Michael J.D."
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Bioactive composites fabricated by freezing-thawing method for bone regeneration applications.
Canillas, Maria; de Lima, Gabriel Goetten; Rodríguez, Miguel A.; Nugent, Michael J.D.; Devine, Declan M. (Wiley, 2016-04)Hydrogels are widely used for controlled delivery of therapeutic agents. However, hydrogels lack bioactivity to encourage bone formation and mechanical integrity. Moreover, chemically crosslinked hydrogels exhibit cytotoxic ... -
Characterization of gels and films produced from Pinhão seed coat nanocellulose as a potential use for wound healing dressings and screening of Its compounds towards antitumour effects
de Lima, Tielidy A. de M.; de Lima, Gabriel Goetten; Chee, Bor Shin; Henn, Jeferson G.; Cortese, Yvonne J.; Matos, Mailson; Helm, Cristiane V.; Magalhães, Washington L.E.; Nugent, Michael J.D. (MDPI, 2022-07-07)The reuse of agro-industrial waste assumes great importance today. Pinhão is the seed of Araucaria angustifolia, which is native to the mountains of southern Brazil, Paraguay, and Argentina. The coat is a by-product of ... -
Design, development and in vitro quantification of novel electrosprayed everolimus-loaded Soluplus®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy
Louis, Lynn; Chee, Bor Shin; McAfee, Marion; Nugent, Michael J.D. (Elsevier, 2023-09-14)Everolimus (RAD001) a mammalian target of rapamycin has been hampered by poor solubility, affecting its dissolution rate, a relationship that extends to low bioavailability. Nanoparticles (NP) based on Soluplus (SOL®) and ... -
Development of electrospun PVA nanofibers via freeze-thawing method
Chee, Bor Shin; Wu, Husheng; Zhu, Wenquan; Masood, Unsa; Sampaio, Viviane Seba; Pereira, Bruno Leandro; Nugent, Michael J.D. (Athlone Institute of Technology, 2019)The polyvinyl alcohol (PVA) hydrogels are proven to have the benefits of improving water retention ability, cell attachment and controlled drug release in medical device materials for pharmaceutical applications. Due to ... -
The development of novel PVA hydrogel for biomedical and drug delivery applications
Chee, Bor Shin (Athlone Institute of Technology, 2021-08)Hydrogels have been used widely in biomaterial applications, mainly due to their low interfacial tension, useful swelling properties and high lubricity. In addition to their promising biocompatibility characteristics, ... -
Development, characterization and cell viability inhibition of PVA spheres loaded with Doxorubicin and 4′-Amino-1-Naphthyl-Chalcone (D14) for osteosarcoma
Seba, Viviane; de Lima, Gabriel Goetten; Periera, Bruno Leandro; Silva, Gabriel; Reinhardt, Luiza Steffens; Arantes, Pablo Ricardo; Shee, Bor Shin; dos Santos, Maria Bastos; França, Suzelei C.; Regasini, Luis Octavio; Fachin, Ana Lúcia; Cao, Zhi; Nugent, Michael J.D.; Marins, Mozart (MDPI, 2021-08-06)Chalcones (1,3-diaryl-2-propen-1-ones) are naturally occurring polyphenols with known anticancer activity against a variety of tumor cell lines, including osteosarcoma (OS). In this paper, we present the preparation and ... -
Effect of cullulose size-concentration on the structure of polyvinyl alcohol hydrogels.
de Lima, Gabriel Goetten; Ferreira, Bruno; Matos, Mailson; Pereira, Bruno Leandro; Nugent, Michael J.D.; Hansel, Fabríco Augusto; Magalhães, Washington Luiz Esteves (Elsevier, 2020-06-11)Microfibrillated cellulose as a reinforcement agent has been investigated extensively due to their unique characteristics, which can reorder the structure of polymers and hydrogels leading to improved mechanical properties ... -
Effect of thermal annealing on a bilayer polyvinyl alcohol/polyacrylic acid electrospun hydrogel nanofibres loaded with doxorubicin and clarithromycin for a synergism effect against osteosarcoma cells
Chee, Bor Shin; de Lima, Gabriel Goetten; de Lima, T.A.M.; Seba, Viviane; Lemarquis, C.; Pereira, Bruno Leandro; Bandeira, Marina; Cao, Zhi; Nugent, Michael J.D. (Elsevier, 2021-08-02)Polyvinyl alcohol/polyacrylic acid (PVA/PAA) bilayer hydrogel nanofibres were successfully fabricated by electrospinning and physically crosslinked via heat treatment. The effects of the thermal annealing process on the ... -
Effect of unidirectional freezing using a thermal camera on polyvinyl (alchohol) for aligned porous cyrogels.
de Lima, Gabriel Goetten; Barbosa, Rêydila Rayenne Caminhas; de Andrade Santos, M.P.; Chee, Bor Shin; Esteves Magalhães, Washington Luiz Esteves; Devine, Declan M.; Nugent, Michael J.D. (Taylor & Francis Online, 2020-03-18)Unidirectional freeze casting for polymers and ceramics has been performed extensively; however, the mechanisms involved in unidirectional freezing are not thoroughly understood and therefore, in this study, polyvinyl ... -
Electrospinning of hydrogels for biomedical applications
de Lima, Gabriel Goetten; Lyons, Sean; Devine, Declan M.; Nugent, Michael J.D. (Springer Nature, 2018)The field of biomedical applications for hydrogels requires the development of nanostructures with specific controlled diameter and mechanical properties. Nanofibers are ideally candidates for these advanced requirements, ... -
Electrospun drug-loaded and gene-loaded nanofibres: the holy grail of glioblastoma therapy?
Louis, Lynn; Chee, Bor Shin; McAfee, Marion; Nugent, Michael J.D. (MDPI, 2023-06-03)To date, GBM remains highly resistant to therapies that have shown promising effects in other cancers. Therefore, the goal is to take down the shield that these tumours are using to protect themselves and proliferate ... -
Evaluation of titanium nitride coatings in bandsaw blades for wood splitting by cold plasma
Lima, Tieldy A.M.; de Lima, Gabriel G.; da Costa, Larissa Nunes; Nugent, Michael J.D.; Magalhães, Washington L.E.; Kuromoto, Neide K. (Taylor & Francis, 2021-11-06)Due to the advances in surface treatments, it is possible to obtain excellent cutting tools. However, the field for wood cutting tools still needs to be further investigated. In this work, titanium nitride was deposited ... -
The influence of mechanical stretching and freeze-thaw processing on the properties of polyvinyl alcohol hydrogels for drug delivery applications
Chee, Bor Shin; De Lima, Gabriel G.; Devine, Declan M.; Nugent, Michael J.D. (Athlone Institute of Technology, 2018-04-24)The study describes the development of physically cross-linked polyvinyl alcohol (PVA) hydrogels using uniaxial orientation via freeze-thawing (F/T). Although cryogels have shown significant improvements in long-term ... -
Machine learning for process monitoring and control of hot-melt extrusion: current state of the art and future directions
Munir, Nimra; Nugent, Michael J.D.; Whitaker, Darren; McAfee, Marion (MDPI, 2021-09-09)In the last few decades, hot-melt extrusion (HME) has emerged as a rapidly growing technology in the pharmaceutical industry, due to its various advantages over other fabrication routes for drug delivery systems. After ... -
Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications
Alibadi, Meysam; Chee, Bor Shin; Matos, Mailson; Cortese, Yvonne J.; Nugent, Michael J.D.; de Lima, Tieilidy A. M.; Magalhães, Washingtonn L.E.; de Lima, Gabriel Goetten; Firouzabadi, Mohammadreza Dehghani (Springer, 2021-06-12)The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols ... -
Nanofibrillated cellulose originated from Rhododendron ponticum to produce scaffolds using 3D printing for biomedical applications
de Lima, Tielidy A. de M.; Goetten de Lima, Gabriel; Munir, Nimra; Coutinho, Joana Raquel Teixeira; Mitchell, Geoffrey Robert; Magalhães, Washington L.E.; Nugent, Michael J.D. (Elsevier, 2023-08-26)Rhododendron ponticum is an invasive species that spreads rapidly and is described as one of the biggest threats to peatlands in Ireland. This study offers an innovative approach to utilizing Rhododendron waste. ... -
Oxide layer containing apatite formed on Ti-25Nb-25Ta alloy treated by two-step plasma electrolytic oxidation.
Pereira, Bruno Leandro; Beilner, Gregory; Lepienski, Carlos Mauricio; Szameitat, Erico Saito; Kuromoto, Neide Kazue; dos Santos, Leonardo Luis; Chee, Bor Shin; Alves Claro, Anna Paula Rosifini; Mazzaro, Irineu; Nugent, Michael J.D. (Elsevier, 2020-01-25)Hydroxyapatite (HA) is a bioactive calcium phosphate capable of enhancing the implant/bone connection improving osteoconductivity and osseointegration process. However, the HA presents mechanical properties limiting its ... -
Preparation and characterization of novel poly(vinyl) (alcohol) (PVA) and poly(acrylic acid) (PAA) hydrogels for sensitive hydrogels.
de Lima, Gabriel Goetten; Devine, Declan M.; de Alencar, Caroline M.; Junqueira, Amanda; Emanuel, Ramon; Nugent, Michael J.D. (Sciforum, 2014-05)Stimuli Sensitive hydrogels have enormous potential in various applications. Various environmental variables are found in the body, such as low pH and elevated temperatures. For this reason, either pH-sensitive and/or ... -
Scratch-resistant and well-adhered nanotube arrays produced via anodizing process on β-titanium alloy
Pereira, Bruno Leandro; Beilner, Gregory; Lepienski, Carlos Mauricio; de Souza, Gelson Biscaia; Kuromoto, Neide Kazue; Szameitat, Erico Saito; Peng, Ambrose Ngu See; Lee, Jia Yee; Claro, Ana Paula Rosifini Alves; Nugent, Michael J.D. (Elsevier, 2021-03)Well-adhered nanotube arrays were produced through the anodizing technique on a Ti-25Nb-25Ta alloy and tribo-mechanically evaluated by nanoindentation and nanoscratch tests. Disregarding substrate effects, the hardness of ... -
Self-photopolymerizable hydrogel-ceramic composites with scavenger properties
Canillas, Maria; Goetten de Lima, Gabriel; De Sá, Marcelo J.C.; Nugent, Michael J.D.; Rodríguez, Miguel A.; Devine, Declan M. (MDPI, 2022-03-21)The photocatalytic behaviours of semiconductive ceramic nanoparticles such as TiO2, ZnO, Fe2O3, and Fe3O4, have been extensively studied in photocatalysis and photopolymerization, due to their ability to produce radical ...