Browsing Technological University of the Shannon: Midlands Midwest by Author "Major, Ian"
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Additive manufacturing of PLA/HNT nanocomposites for biomedical applications
Venkatesh, Chaitra; Fuenmayor, Evert; Doran, Patrick; Major, Ian (Elsevier, 2019)Additive manufacturing has been of great interest of research in various applications due to their ease in processability, cost effectiveness and adaptability. In this study Poly Lactic Acid (PLA) was used as the base ... -
A bilayer vaginal tablet for the localized delivery of disulfiram and 5-fluorouracil to the cervix
Abidin, Ismin Zainol; Rezoagli, Emanuele; Simonassi-Paiva, Bianca; Fehrenbach, Gustavo Waltzer; Masterson, Kevin; Pogue, Robert; Cao, Zhi; Rowan, Neil; Murphy, Emma J.; Major, Ian (MDPI, 2020-12-06)This study was performed to develop an adjuvant therapy in the form of a self-administered vaginal tablet regimen for the localized delivery of chemotherapeutic drugs. This therapy will help to reduce relapse by eradicating ... -
Characteristics of the treated calcium carbonate particles with stearic acid using different treating methods.
Cao, Zhi; Daly, Michael; Clémence, Lopez; Major, Ian; Higginbotham, Clement L.; Devine, Declan M. (Elsevier, 2016-08)Calcium carbonate (CaCO3) is often treated with stearic acid (SA) to decrease its polarity. However, the method of application of the SA treatments has a strong influence on their interface structure and distribution. ... -
Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets.
Fuenmayor, Evert; Forde, Martin; Healy, Andrew V.; Devine, Declan M.; Lyons, John G.; McConville, Christopher; Major, Ian (Elsevier, 2019-03-10)Oral tablets are a convenient form to deliver active pharmaceutical ingredients (API) and have a high level of acceptance from clinicians and patients. There is a wide range of excipients available for the fabrication of ... -
Designing sustainable polymer blends: tailoring mechanical properties and degradation behaviour in PHB/PLA/PCL blends in a seawater environment
Engler, Leonardo; Farias, Naiara C.; Crespo, Janaina S.; Gately, Noel M.; Major, Ian; Pezzoli, Romina; Devine, Declan M. (MDPI, 2023-06-29)Biodegradable polyesters are a popular choice for both packaging and medical device manufacture owing to their ability to break down into harmless components once they have completed their function. However, commonly used ... -
Development and in vitro evaluation of an alternative thermo-tolerant antimicrobial polymer for the prevention and treatment of bovine mastitis
Masterson, Kevin (Technological University of the Shannon: Midlands Midwest, 2023-05)Despite advancements in veterinary medicine, bovine mastitis remains one of the most significant and prevalent diseases in Irish dairy herds. Raw milk represents one of Ireland’s main food exports and as DAFM Food-Wise ... -
Development of a low-temperature extrusion process for production of GRAS bioactive-polymer loaded compounds for targeting antimicrobial-resistant (AMR) bacteria
Masterson, Kevin; Meade, Elaine; Garvey, Mary; Lynch, Mark; Major, Ian; Rowan, Neil J. (Elsevier, 2021-08-10)Antimicrobial resistance (AMR) is recognised globally as one of the greatest threats to human and animal health; thus, discovery of alternative antibacterial agents to address AMR is a priority challenge. This study ... -
Development of a multi-layered vaginal tablet containing Dapivirine, Levonorgestrel and Acyclovir for use as a multipurpose prevention technology.
McConville, Christopher; Major, Ian; Devlin, Brid; Brimer, Andrew (Elsevier, 2016-07)Multipurpose prevention technologies (MPTs) are preferably single dosage forms designed to simultaneously address multiple sexual and reproductive health needs, such as unintended pregnancy, HIV infection and other ... -
Development of disulfiram-loaded vaginal rings for the localised treatment of cervical cancer.
Boyd, Peter; Major, Ian; Wang, Weiguang; McConville, Christopher (Elsevier, 2014-11)Cervical cancer is the third most prevalent cancer in women and disproportionately affects those in low resource settings due to limited programs for screening and prevention. In the developed world treatment for the disease ... -
Development of drug eluting biodegradable nanocomposite for use in coronary stents
Venkatesh, Chaitra (Athlone Institute of Technology, 2021-07)Coronary stents are the scaffolds placed inside the blocked arteries, which aids the restoration of the passage of blood to the heart. Coronary stenting has become a standard medical procedure to treat coronary heart disease ... -
Development of high strength nanocomposite for biodegradable stents
Venkatesh, Chaitra; Chen, Yuanyuan; Cao, Zhi; Brennan, Shane; Major, Ian; Lyons, John G.; Devine, Declan M. (Athlone Institute of Technology, 2018-04-24)The use of biodegradable polymer materials are considered to be good alternatives in urology (Donohue et. al. 2018), cardiovascular (Brie et. al. 2016) and tracheal airway stenosis which provide support before it is absorbed ... -
Effect of stereolithography 3D printing on the properties of PEGDMA hydrogels.
Burke, Gavin; Major, Ian; Devine, Declan (MDPI, 2020-09-03)Stereolithography (SLA)-based 3D printing has proven to have several advantages over traditional fabrication techniques as it allows for the control of hydrogel synthesis at a very high resolution, making possible the ... -
Extruded monofilament and multifilament thermoplastic stitching yarns.
McGarrigle, Cormac; Rodgers, Ian; McIlhagger, Alistair; Harkin-Jones, Eileen; Major, Ian; Devine, Declan; Archer, Edward (MDPI, 2017-12)Carbon fibre reinforced polymer composites offer significant improvement in overall material strength to weight, when compared with metals traditionally used in engineering. As a result, they are replacing metals where ... -
Fused-filament fabrication of PEEK: a review of process-structure-property relationships.
Zanjanijam, Ali Reza; Major, Ian; Lyons, John G.; Lafont, Ugo; Devine, Declan M. (MDPI, 2020-07-27)Poly (ether ether ketone) (PEEK) is a high-performance engineering thermoplastic polymer with potential for use in a variety of metal replacement applications due to its high strength to weight ratio. This combination ... -
Hyaluronic acid: a review of the drug delivery capabilities of this naturally occurring polysaccharide
Buckley, Ciara; Murphy, Emma J.; Montgomery, Therese R.; Major, Ian (MDPI, 2022-08-23)The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially ... -
Hybrid manufacturing 3D printing and injection moulding in the pursuit of mass customization
Gong, Ke; Major, Ian; Devine, Declan; Cao, Zhi (Athlone Institute of Technology, 2020-06)Project Overview: Mass customization is a marketing and manufacturing technique which combines the flexibility and personalization of custom-made products with the low unit costs associated with mass production. The ... -
Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions
Murphy, Emma J.; Rezoagli, Emanuele; Pogue, Robert; Simonassi-Paiva, Bianca; Abidin, Ismin Izwani Zainol; Fehrenbach, Gustavo Waltzer; O'Neil, Emer; Major, Ian; Laffey, John G.; Rowan, Neil J. (Elsevier, 2022-02-25)Acute respiratory distress syndrome (ARDS) is the most common form of acute severe hypoxemic respiratory failure in the critically ill with a hospital mortality of 40%. Alveolar inflammation is one of the hallmarks for ... -
Influence of annealing and biaxial expansion on the properties of Poly-l-lactic) medical tubing.
Dillon, Brian; Doran, Patrick; Fuenmayor, Evert; Healy, Andrew V.; Gately, Noel M.; Major, Ian; Lyons, John G. (MDPI, 2019-07-11)Poly-l-lactic acid (PLLA) is one of the most common bioabsorbable materials in the medical device field. However, its use in load-bearing applications is limited due to its inferior mechanical properties when compared ... -
Influence of extrusion screw speed on the properties of halloysite nanotube impregnated polylactic acid nanocomposites
Venkatesh, Chaitra; Chen, Yuanyuan; Cao, Zhi; Brennan, Shnae; Major, Ian; Lyons, John G.; Devine, Declan M. (De Gruyter, 2021)Poly (lactic acid)/halloysite nanotube (PLA/HNT) nanocomposites have been studiedextensively over the past fewyears owing to the interesting properties of the polymer, PLA, and the nanoclay, HNT, individually and as ... -
The influence of low shear microbore extrusion on the properties of high molecular weight poly(l-lactic acid) for medical tubing applications.
Dillon, Brian; Doran, Patrick; Fuenmayor, Evert; Healy, Andrew V.; Gately, Noel M.; Major, Ian; Lyons, John G. (MDPI, 2019-04)Biodegradable polymers play a crucial role in the medical device field, with a broad range of applications such as suturing, drug delivery, tissue engineering, sca olding, orthopaedics, and fixation devices. Poly-l-lactic ...