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dc.contributor.authorBarbosa, William Teles
dc.contributor.authorde Almeida, Katilayne Vieira
dc.contributor.authorde Lima, Gabriel Goetten
dc.contributor.authorRodriguez, Miguel A.
dc.contributor.authorFook, Marcus V. Lia
dc.contributor.authorGarcía-Carrodeguas, Raul
dc.contributor.authorAvelino, Monique Silva
dc.contributor.authorSegundo, Francisco Alipio de Sousa
dc.contributor.authorde Sá, Marcelo Jorge Cavalcanti
dc.identifier.citationBarbosa, W. T., de Almeida, K. V., De Lima, G.G., Rodriguez, M.A., Fook, M.V. L., García-Carrodeguas, R., Avelino, M.S., Segundo, F.A.D.S., de Sá, M.J.C. (2019). Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model. Journal of Biomedical Materials Research. Part B. Applied Biomaterials. 8 August.
dc.identifier.otherArticles - Materials Research Instituteen_US
dc.description.abstractScaffolds are models designed to aid the interaction between cells and extracellular bone matrix, providing structural support for newly formed bone tissue. In this work, wollastonite with β‐TCP porous ceramic scaffolds was developed by the polymer sponge replication. Their microstructure, cell viability and bioactivity were tested. in vivo was performed to evaluate the use of a calcium silicate‐based implant in the repair of rabbit tibias. Holes were made in the both proximal and distal tibial metaphysis of each animal and filled with calcium silicate‐based implant, and in the left tibia, no implant were used, serving as control group. Animals underwent euthanasia after 30 and 60 days of study. The animals were submitted to clinical‐radiographic evaluations and their histology was analyzed by optical and scanning electron microscope. The studied calcium silicate implant provided biocompatibility and promoted bone formation, stimulating the process of bone repair in rabbits, features observed by gradual radiopacity shown in the radiographic evaluations.en_US
dc.publisherWiley Online Libraryen_US
dc.relation.ispartofJournal of Biomedical Materials Research. Part B. Applied Biomaterials.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.subjectCalcium phosphateen_US
dc.subjectCalcium silicateen_US
dc.subjectBone regenerationen_US
dc.titleSynthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model.en_US
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute - AITen_US

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