Browsing Articles - PRISM: Polymer, Recycling, Industrial, Sustainability and Manufacturing Institute by Author "Walker, Gavin M."
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The effect of cooling on the degree of crystallinity, solid-state properties, and dissolution rate of multi-component hot-melt extruded solid dispersions.
Hurley, Dean; Davis, Mark; Walker, Gavin M.; Lyons, John G.; Higginbotham, Clement L. (MDPI, 2020-03-01)The effect of cooling on the degree of crystallinity, solid-state and dissolution properties of multi-component hot-melt extruded solid dispersions [SD] is of great interest for the successful formulation of amorphous ... -
Investigation of ethylene oxide-co-propylene oxide for dissolution enhancement of hot-melt extruded solid dispersions.
Hurley, Dean; Potter, Catherine J.; Walker, Gavin M.; Higginbotham, Clement L. (Elsevier, 2018-02)The optimal design of amorphous solid dispersion (ASD) formulations requires the use of excipients to maintain supersaturation and improve physical stability in order to ensure shelf-life stability and better absorption ... -
An investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed Copovidone hot-melt extruded solid dispersions.
Hurley, Dean; Carter, David; Ng, Lawrence Yee Foong; Davis, Mark; Walker, Gavin M.; Lyons, John G.; Higginbotham, Clement L. (Elsevier, 2019-10)Previous research has focused on spray dried quaternary mixtures which due to the addition of a surfactant 26 affected the physical stability and amorphous stability of selected model drugs. Very little research has 27 ...