Browsing Articles - PRISM: Polymer, Recycling, Industrial, Sustainability and Manufacturing Institute by Author "Higginbotham, Clement L."
Now showing items 1-19 of 19
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Additive manufacturing of personalized pharmaceutical dosage forms via stereolithography.
Healy, Andrew V.; Fuenmayor, Evert; Doran, Patrick; Geever, Luke M.; Higginbotham, Clement L.; Lyons, John G. (MDPI, 2019-12-03)The introduction of three-dimensional printing (3DP) has created exciting possibilities for the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage forms of two drug ... -
Analysis of the mechanical properties of solvent cast blends of PLA/PCL.
Chen, Yuanyuan; Geever, Luke M.; Higginbotham, Clement L.; Devine, Declan M. (Trans Tech Publications, 2014-09)Polylactic acid (PLA) is the most promising material in the biodegradable category. However, brittleness and poor thermal stability restrict its application. To overcome this limitation, PLA may be blended with other ... -
Characteristics of the treated calcium carbonate particles with stearic acid using different treating methods.
Cao, Zhi; Daly, Michael; Clémence, Lopez; Major, Ian; Higginbotham, Clement L.; Devine, Declan M. (Elsevier, 2016-08)Calcium carbonate (CaCO3) is often treated with stearic acid (SA) to decrease its polarity. However, the method of application of the SA treatments has a strong influence on their interface structure and distribution. ... -
Development of synthetic alternatives for bone tissue engineering.
Killion, John; Geever, Luke; Devine, Declan; Kennedy, James; Higginbotham, Clement L. (Australian Journal of Basic and Applied Sciences, 2013)Due to the inherent limitations of current biological bone grafts, alternative synthetic substitutes are being pursued. Therefore, this study aimed to improve the bioactive and compressive properties of photopolymerisable ... -
Durum wheat seed germination response to hydrogel coatings and moisture under drought stress.
Morris, Noreen; Hotta, Maya; Kennedy, James; Higginbotham, Clement L. (Science Publications, 2016-11)Abstract: Technologies that can increase crop production while maintaining low pollution are essential for sustainable agriculture. This study compares the germination performance of Durum wheat seeds (Triticum durum ... -
Effect of Chemical Treatments and HDPE-g-MA on the physical and mechanical behaviour of HDPE/ natural fibre composites.
Cao, Zhi; Peyregne, Marc; Daly, Michael; Mullen, Tom; Devine, Declan M.; Geever, Luke; Higginbotham, Clement L. (2013)Many authors have reported on the use of natural fibres (raw or chemically modified) as reinforcing elements for high density polyethylene (HDPE). These materials have generated a lot of interest due to their low cost ... -
The effect of cooling on the degree of crystallinity, solid-state properties, and dissolution rate of multi-component hot-melt extruded solid dispersions.
Hurley, Dean; Davis, Mark; Walker, Gavin M.; Lyons, John G.; Higginbotham, Clement L. (MDPI, 2020-03-01)The effect of cooling on the degree of crystallinity, solid-state and dissolution properties of multi-component hot-melt extruded solid dispersions [SD] is of great interest for the successful formulation of amorphous ... -
Halloysite nanotube reinforced polylactic acid composite.
Chen, Yuanyuan; Geever, Luke M.; Killion, John; Lyons, John G.; Higginbotham, Clement L. (Wiley, 2017-10)Polylactic acid (PLA) has long history in medical applications, and reinforced PLA has the potential to be used in the medical applications that require high mechanical strength such as coronary stents and bone fixation ... -
Investigation of ethylene oxide-co-propylene oxide for dissolution enhancement of hot-melt extruded solid dispersions.
Hurley, Dean; Potter, Catherine J.; Walker, Gavin M.; Higginbotham, Clement L. (Elsevier, 2018-02)The optimal design of amorphous solid dispersion (ASD) formulations requires the use of excipients to maintain supersaturation and improve physical stability in order to ensure shelf-life stability and better absorption ... -
Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate).
Pezzoli, Romina; Lyons, John G.; Gatley, Noel; Higginbotham, Clement L. (Elsevier, 2018)The investigation of the miscibility between active pharmaceutical ingredients (API’s) and polymeric excipients is of great interest for the formulation and development of amorphous solid dispersions, especially in the ... -
An investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed Copovidone hot-melt extruded solid dispersions.
Hurley, Dean; Carter, David; Ng, Lawrence Yee Foong; Davis, Mark; Walker, Gavin M.; Lyons, John G.; Higginbotham, Clement L. (Elsevier, 2019-10)Previous research has focused on spray dried quaternary mixtures which due to the addition of a surfactant 26 affected the physical stability and amorphous stability of selected model drugs. Very little research has 27 ... -
Micro-injection moulding of poly(vinylpyrrolidone-vinyl acetate) binary and ternary amorphous solid dispersions.
Pezzoli, Romina; Hopkins, Michael Jnr.; Direur, Guillaume; Gatley, Noel; Lyons, John G.; Higginbotham, Clement L. (MDPI, 2019-05)Micro-injection moulding (µIM) was used for the production of enteric tablets of plasticised and unplasticised solid dispersions of poly(vinylpyrrolidone-vinyl acetate) (PVPVA), and the effect of the mechanical and thermal ... -
Preparation of a novel freeze thawed poly (vinly alcohol) composite hydrogel for drug delivery applications
Nugent, Michael J.; Higginbotham, Clement L. (Elsevier, 2007-09)Poly(vinyl alcohol) (PVA) is a water-soluble, biocompatible and biodegradable polymer, which has been widely applied in biomedical fields. In this paper, novel physically cross-linked hydrogels composed of PVA and comprising ... -
Processing and characterisation of various polymer blends to develop implant for tissue engineering applications.
Kenny, Elaine; Devine, Declan M.; Higginbotham, Clement L.; Geever, Luke (AESS, 2013)In the past two decades, the repair and reconstruction of musculoskeletal tissues using biodegradable scaffold materials has emerged as one of the most promising approaches in tissue engineering. The aim of this study ... -
Reinforced polylactic acid for use in high strength biodegradable medical implants.
Chen, Yuanyuan; Geever, Luke; Higginbotham, Clement L.; Killion, John; Lyons, John; Devine, Declan M. (2016)Traditional medical implants, such as orthopedic screws, pins, and coronary stents, are almost exclusively metallic due to high mechanical strength requirements. However, issues related to the use of permanent metallic ... -
Review of multifarious applications of Poly (lactic acid)
Chen, Yuanyuan; Geever, Luke M.; Killion, John A.; Lyons, John G.; Higginbotham, Clement L. (Taylor & Francis, 2016)Poly (lactic acid) is considered to be a promising alternative to petroleum-based polymers due to its renewability, biodegradability, biocompatibility, and good mechanical properties. Because of the high cost, the applications ... -
Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble Indomethacin with Poly(vinyl pyrrolidone-co-vinyl acetate) and polyethylene oxide.
Pezzoli, Romina; Lyons, John G.; Gatley, Noel; Higginbotham, Clement L. (Elsevier, 2019-08)This investigation aims to evaluate the effect of moisture and temperature on the physical stability and dissolution behaviour of hot-melt extruded binary and plasticised ternary solid dispersions. Poorly water-soluble ... -
Synthesis and characterization of high density polyethylene / peat ash composites.
Cao, Zhi; Daly, Michael; Geever, Luke M.; Higginbotham, Clement L.; Devine, Declan M. (Elsevier, 2016-06)A new type of polymer composite was synthesized from one industrial waste, peat ash, at varying mixing ratios of high density polyethylene (HDPE) and the resulting products were characterized using different experiments ... -
Synthesis of linear aliphatic polycarbonate macroglycols using dimethylcarbonate.
Foy, Ernest; Farrell, Joseph; Higginbotham, Clement L. (Wiley, 2009-01-05)A series of linear aliphatic polycarbonate polyols were synthesized using dimethylcarbonate and a linear alkane diol or specific combinations of linear alkane diols. Polyol synthesis was carried out in a two‐stage process ...