Browsing Articles - Bioscience Research Institute (BRI) by Author "MacHugh, David E."
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Alveolar macrophage chromatic is modified to orchestrate host response to Mycobacterium bovis infection.
Hall, Thomas J.; Vernimmen, Douglas; Browne, John A.; Mullen, Michael P.; Gordon, Stephen V.; MacHugh, David E.; O'Doherty, Alan M. (Frontiers, 2019-02-07)Bovine tuberculosis is caused by infection with Mycobacteriumbovis, which can also cause disease in a range of other mammals, including humans. Alveolar macrophages are the key immune effector cells that first encounter ... -
Integrative genomics of the mammalian alveolar macrophage response to intraceullular mycobacteria
Hall, Thomas J.; Mullen, Michael P.; McHugo, Gillian; Killick, Kate E.; Ring, Siobhán C.; Berry, Donagh P.; Correia, Carolina N.; Browne, John A.; Gordon, Stephen V.; MacHugh, David E. (BMC, 2021)Bovine TB (bTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting global cattle production. The key innate immune cell that first encounters the pathogen is the alveolar macrophage, ...