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Fetuin-A as a potential biomarker of metabolic variability following 60 days of bed rest
(Frontiers Media, 2020-10-19)
Background: Fetuin-A is a hepatokine linked to the development of insulin resistance. The purpose of this study was to determine if 60 days head-down-tilt (HDT) bed rest increased circulating fetuin-A and if it was linked ...
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
(Elsevier, 2010-02-01)
Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer’s Disease (AD). They are stable in human plasma but in mouse plasma they ...
A pragmatic randomised controlled trial of an implementation intervention to increase healthy eating and physical activity-promoting policies, and practices in centre-based childcare services: study protocol.
(BMJ, 2015)
Background Promotion of healthy eating and physical activity in early childhood is recommended as a global chronic disease prevention strategy. Centre-based childcare services represent a promising setting to provide ...
Validation of the W@WApp + MetaWearC sensor to monitor occupational sitting, standing and stepping in office employees: validation study.
(JMIR, 2020-05-14)
Background:
Replacing occupational sitting time with active tasks has several proposed health benefits for office employees. Smartphones and motion sensors, can provide objective information in real time on occupational ...
Fitness profiling of elite level adolescent Gaelic football players.
(National Strength and Conditioning Association, 2013-08)
The purpose of this study was to evaluate the anthropometric characteristics and fitness levels of elite level under 18 (U-18) Gaelic football players to establish normative centile scores for selected fitness parameters ...
The "proof" of the pudding is not just in the eating. Savouring the richness of the research process experience
(Everthing is Connected Press, 2021)
There is much written on research methodologies and the merits of each within academic texts. Researchers provide written accounts of their methodologies, their results locating these in literature previously reviewed. New ...
The effect of muscle energy techniques on latent trigger points of the gastrocnemius muscle
(United States Sports Academcy, 2021-02-12)
Purpose: The purpose of this study is to examine the effectiveness of muscle energy technique post isometric relaxation as a treatment method for latent trigger points within the gastrocnemius muscle. This study also ...
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase.
(Elsevier, 2008-09-25)
We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ...
Parents' perspectives of the transition to home when a child has complex technological health care needs.
(Ubiquity Press, 2015-09-29)
Introduction: There is an increasing number of children with complex care needs, however, there is limited evidence of the experience
of families during the process of transitioning to becoming their child’s primary care ...
In vitro metabolism of the synthetic cannabinoid 3,5‐AB‐CHMFUPPYCA and its 5,3‐regioisomer and investigation of their thermal stability.
(Wiley, 2016-02)
Recently, the pyrazole‐containing synthetic cannabinoid N‐(1‐amino‐3‐methyl‐1‐oxobutan‐2‐yl)‐1‐(cyclohexylmethyl)‐3‐(4‐fluorophenyl)‐1H‐pyrazole‐5‐carboxamide (3,5‐AB‐CHMFUPPYCA) has been identified as a ‘research chemical’ ...