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Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble Indomethacin with Poly(vinyl pyrrolidone-co-vinyl acetate) and polyethylene oxide.
(Elsevier, 2019-08)
This investigation aims to evaluate the effect of moisture and temperature on the physical
stability and dissolution behaviour of hot-melt extruded binary and plasticised ternary solid
dispersions. Poorly water-soluble ...
Faster release of lumen-loaded drugs than matrix-loaded equivalent in polylactic acid/halloysite nanotubes.
(MDPI, 2019-06-15)
Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based ...
Surface modified halloysite nanotubes reinforced polylactic acid for use in biodegradable coronary stents.
(Wiley, 2019-08)
Poly(lactic acid) (PLA) was reinforced halloysite nanotubes (HNTs) in this study. To improve dispersion and interfacial adhesion of HNTs within the PLA matrix, HNTs were surface modified with 3‐aminopropyltriethoxysilane ...
Material considerations for fused-filament fabrication of solid dosage forms.
(MDPI, 2018-04-02)
Material choice is a fundamental consideration when it comes to designing a solid dosage form. The matrix material will ultimately determine the rate of drug release since the physical properties (solubility, viscosity, ...
An investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed Copovidone hot-melt extruded solid dispersions.
(Elsevier, 2019-10)
Previous research has focused on spray dried quaternary mixtures which due to the addition of a surfactant 26 affected the physical stability and amorphous stability of selected model drugs. Very little research has 27 ...
Polymer based additive manufacturing historical developments, process types and material considerations.
(Springer Nature, 2019)
3D printing is a manufacturing technique where parts are built in a layer-by-layer fashion. The earliest embodiments were based on generating successive layers of solidified materials at the air liquid interface through ...
NIR-based intelligent sensing of product yield stress for high-value bioresorbable polymer processing
(MDPI, 2022-04-07)
PLA (polylactide) is a bioresorbable polymer used in implantable medical and drug
delivery devices. Like other bioresorbable polymers, PLA needs to be processed carefully to avoid
degradation. In this work we combine ...
Thermal, mechanical, dieletric and morphological study of dieletric filler based thermoplastic nano-composites for smart applications.
(Sage, 2019-02-01)
Dielectric nanocomposite elastomers based on poly(styrene-ethylene/butylene-styrene) (SEBS) and SEBS-grafted-maleic anhydride (SEBS-g-MA) with barium titanate (BT) suitable for electroactive applications were successfully ...
Additive manufacturing of personalized pharmaceutical dosage forms via stereolithography.
(MDPI, 2019-12-03)
The introduction of three-dimensional printing (3DP) has created exciting possibilities for
the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage
forms of two drug ...
Degradable polymer nanocomposites for fused filament fabrication applications
(Athlone Institute of Technology, 2018-04-24)
The use of plastics in everyday life has increased dramatically during the course of the 20th and 21st century which is primarily due to the characteristics plastics offer in the development of new products to meet the ...