Browsing Technological University of the Shannon: Midlands Midwest by Author "Yan, Guangming"
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Enhancing drug solubility through advanced polymer extruded shellac-based matrix drug delivery systems
Yan, Guangming (Technological University of the Shannon: Midlands Midwest, 2022-09)The main objective of this study is to enhance the solubility of the model drug fenofibrate, by forming amorphous solid dispersions using a hot melt extrusion process. Hot melt extrusion offers an efficient way of ... -
Hot melt enteric targeted therapeutic delivery platform: enhancing drug solubility through advanced polymer extruded delivery system
Yan, Guangming; Cao, Zhi; Devine, Declan; Gately, Noel (TUS Midlands Midwest, 2022)Cardiovascular diseases (CVDs) are the number 1 cause of death globally. Fenofibrate has been shown an excellent treating effect on CVDs. However, Fenofibrate is a neutral, lipophilic compound that is practically insoluble ... -
"My heart, your heart"; hot melt enteric targeted therapeutic delivery platform: enhancing drug solubility through advanced polymer extruded drug delivery system
Yan, Guangming; Cao, Zhi; Devine, Declan; Gatley, Noel (Athlone Institute of Technology, 2020-06)Cardiovascular diseases (CVDs) are the number 1 cause of death globally. Fenofibrate has been shown an excellent treating effect on CVDs. However, Fenofibrate is a neutral, lipophilic compound that is practically insoluble ... -
Physical properties of shellac material used for hot melt extrusion with potential application in the pharmaceutical industry
Yan, Guangming; Cao, Zhi; Devine, Declan; Penning, Manfred; Gately, Noel M. (MDPI, 2021-10-28)Hot melt extrusion offers an efficient way of increasing the solubility of a poorly soluble drug. Shellac has potential as a pharmaceutical matrix polymer that can be used in this extrusion process, with further advantages ...