Browsing Technological University of the Shannon: Midlands Midwest by Author "Laffey, John G."
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Challenges and solutions for addressing critical shortage of supply chain for personal and protective equipment (PPE) arising from Coronavirus disease (COVID19) pandemic - case study from the Republic of Ireland.
Rowan, Neil J.; Laffey, John G. (Elsevier, 2020-04-05)Coronavirus (COVID-19) is highly infectious agent that causes fatal respiratory illnesses, which is of great global public health concern. Currently, there is no effective vaccine for tackling this COVID19 pandemic where ... -
Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions
Murphy, Emma J.; Rezoagli, Emanuele; Pogue, Robert; Simonassi-Paiva, Bianca; Abidin, Ismin Izwani Zainol; Fehrenbach, Gustavo Waltzer; O'Neil, Emer; Major, Ian; Laffey, John G.; Rowan, Neil J. (Elsevier, 2022-02-25)Acute respiratory distress syndrome (ARDS) is the most common form of acute severe hypoxemic respiratory failure in the critically ill with a hospital mortality of 40%. Alveolar inflammation is one of the hallmarks for ... -
Purified β‐glucans from the Shiitake mushroom ameliorates antibiotic‐resistant Klebsiella pneumoniae‐induced pulmonary sepsis
Masterson, Claire H.; Murphy, Emma J.; Gonzalez, H.; Major, Ian; McCarthy, S.D.; O'Toole, D.; Laffey, John G.; Rowan, Neil J. (Society for Applied Microbiology, 2020-07-24)Bacterial infection remains the main cause of acute respiratory distress syndrome and is a leading cause of death and disability in critically ill patients. Here we report on the use of purified β‐glucan (lentinan) extracts ... -
Unlocking the surge in demand for personal and protective equipment (PPE) and improvised face coverings arising from coronavirus disease (COVID-19) pandemic – Implications for efficacy, re-use and sustainable waste management
Rowan, Neil J.; Laffey, John G. (Elsevier, 2021)Currently, there is no effective vaccine for tackling the ongoing COVID-19 pandemic caused by SARS-CoV-2 with the occurrence of repeat waves of infection frequently stretching hospital resources beyond capacity. Disease ... -
β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects — Implications for coronavirus disease (COVID-19) immunotherapies.
Murpyhy, Emma J.; Masterson, Claire; Rezoagli, Emanuele; O'Toole, Daniel; Major, Ian; Stack, Gary D.; Lynch, Mark; Laffey, John G.; Rowan, Neil J. (Elsevier, 2020-05-11)Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute respiratory distress syndrome (ARDS) and death. ... -
β-glucan metabolic and immunomodulatory properties and potential for clinical application
Murphy, Emma J.; Rezoagli, Emanuele; Major, Ian; Rowan, Neil J.; Laffey, John G. (MDPI, 2020-12-10)β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties. β-glucans have metabolic and gastro-intestinal effects, ...