The integration of nanotechnology into biomedical applications is called “nanomedicine”. Nanomedicine has the ability to change properties of materials at the molecular and atomic level . Numerous methods have been employed to generate biomaterials in nanoscales. One such method is electrospinning which is regarded as a versatile, inexpensive and simple methodology to fabricate materials with sizes in the nanometre range . Different drug release profiles: fast release, sustainable release, biphasic release (i.e. quick/slow system, slow/quick system), triphasic release can be tailored using electrospun nanofibres. This study aims to fabricate polyvinyl alcohol (PVA) hydrogel nanofibres encapsulated with propolis extract which can introduce a biphasic drug delivery system.