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Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
(Elsevier, 2010-02-01)
Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer’s Disease (AD). They are stable in human plasma but in mouse plasma they ...
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase.
(Elsevier, 2008-09-25)
We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ...