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dc.contributor.authorLouis, Lynn
dc.contributor.authorChee, Bor Shin
dc.contributor.authorLouis, Noreen
dc.contributor.authorGoetten de Lima, Gabriel
dc.contributor.authorMcAfee, Marion
dc.date.accessioned2023-03-14T15:31:17Z
dc.date.available2023-03-14T15:31:17Z
dc.date.copyright2023
dc.date.issued2023-02-02
dc.identifier.citationLouis, L., Chee, B.S., Louis, N., Goetten de Lima, G., McAfee, M., Murphy, A., Nugent, M.J.D. (2023). Novel polyvinyl-alcohol microsphere for everolimus delivery for subependymal cell astrocytoma. Journal of Drug Delivery Science and Technology.81: 104204. https://doi.org/10.1016/j.jddst.2023.104204en_US
dc.identifier.issn1773-2247
dc.identifier.urihttps://research.thea.ie/handle/20.500.12065/4430
dc.description.abstractEverolimus (EVR) has demonstrated efficacy in treating subependymal giant cell astrocytoma (SEGA) and other tuberous sclerosis (TSC) manifestations. Oral use of EVR is associated with low bioavailability and systemic toxicities culminating in treatment cessation in an appreciable patient population. To circumvent undesired effects, we developed a microsphere embedded formulation of EVR using polyvinyl alcohol (PVA) with an endgoal to achieve higher bioavailability and sustained delivery. PVA-EVR microspheres were physically cross-linked using the freeze-thaw technique, and solvent-cast PVAEVR films were developed as a control, without freezing and thawing cycles to ascertain the techniques significance. In vitro analyses and characterisation was performed to determine drug release and drug-polymer compatibility whereas In silico studies was done to analyse the non-crosslinked polymer and to evaluate qualitatively the interaction between EVR and PVA. The PVA-EVR microspheres were found to have high encapsulation efficiency, resulting in sustained release of EVR when compared to solvent cast films. The molecular docking studies showed excellent compatibility of the drug-polymer combination, further confirmed by the characterisation studies performed using DSC, FTIR, SEM and XRD. The developed PVA-EVR microspheres in this study can serve as a highly effective drug-delivery system with better bioavailability in treating SEGA tumours.en_US
dc.formatPDFen_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectSupependymal giant cell astrocytomaen_US
dc.subjectEverolimusen_US
dc.subjectPolyvinyl alcoholen_US
dc.subjectDrug delivery systemsen_US
dc.subjectDrug-release kineticsen_US
dc.subjectFreeze-thawingen_US
dc.titleNovel polyvinyl-alcohol microsphere for everolimus delivery for subependymal cell astrocytomaen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.contributor.affiliationTechnological University of the Shannon: Midlands Midwesten_US
dc.contributor.sponsorTechnological University of the Shannon [President’s Doctoral Scholarship].en_US
dc.description.peerreviewyesen_US
dc.identifier.doi10.1016/j.jddst.2023.104204en_US
dc.identifier.eissn2588-8943
dc.identifier.orcidhttps://orcid.org/0000-0002-4720-652Xen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1606-1759en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7469-4389en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7469-4389en_US
dc.identifier.volume81en_US
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.departmentMaterials Research Institute TUS: MMen_US
dc.type.versioninfo:eu-repo/semantics/publishedVersionen_US


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States