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dc.contributor.authorTalbot, Anita
dc.contributor.authorMcCormack, Michelle
dc.contributor.authorDwivedi, Ankit
dc.contributor.authorO'Connor, Ian
dc.contributor.authorValdenegro, Victoria
dc.contributor.authorMacCarthy, Eugene
dc.identifier.citationAnita Talbot, Michelle McCormack, Ankit Dwivedi, Ian O'Connor, Victoria Valdenegro, Eugene MacCarthy, Investigation into the potential use of dietary supplementation to reduce the impact of Amoebic Gill Disease, Aquaculture, Volume 552, 2022, 737983, ISSN 0044-8486,
dc.description.abstractAmoebic Gill Disease (AGD) is a disease affecting cultured Atlantic salmon (Salmo salar) which is caused by Paramoeba perurans. The immunomodulatory impact of functional foods has previously been demonstrated in salmon. The aim of this study was to investigate the role of a novel fish feed in mitigating the severity and progression of AGD in Atlantic salmon. Negative and positive control fish were maintained on a base fish feed, with experimental fish maintained on a customized feed blend pre- and post-amoeba inoculation. Disease progression was evaluated using gill scoring and diagnostic quantitative real-time polymerase chain reaction (qPCR) for the detection of P. perurans at 14 and 21 dpi. The expression profiles of 11 immune related genes were analyzed by qPCR at 14 and 21 dpi. The customized feed blend was shown to delay the onset of clinical symptoms associated with AGD. Furthermore, the expression of genes with roles in maintenance of the mucosal layer and mucosal defense were impacted in fish fed on this novel feed formulation.en_US
dc.publisherElsevier Ltden_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.subjectAmoebic Gill Disease (AGD)en_US
dc.subjectParamoeba peruransen_US
dc.subjectAtlantic salmonen_US
dc.subjectGene expressionen_US
dc.titleInvestigation into the potential use of dietary supplementation to reduce the impact of Amoebic Gill Diseaseen_US
dc.contributor.affiliationMarine and Freshwater Research Centre, Galway Mayo Institute of Technology, Galway, Irelanden_US
dc.contributor.affiliationBioMar AS, Havnegata 9, Pirsenteret, Trondheim 7043, Norwayen_US
dc.subject.departmentMarine and Freshwater Research Centreen_US

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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International