HLA is a human endogenous biopolysaccharide discovered by Karl Meyer in 1938, in the vitreous
humour of bovine eyes and is a key component of the extracellular matrix (ECM) found in every cell
type in the body. It is naturally synthesized by a class of integral membrane proteins called
hyaluronan synthases, and degraded by a family of enzymes called hyaluronidases.