Show simple item record

dc.contributor.authorUsuldin, Siti Rokhiyah Ahmad
dc.contributor.authorWan-Mohtar, Irmad
dc.contributor.authorIlham, Zul
dc.contributor.authorJamaludin, Adi Alnurzaman
dc.contributor.authorAbdullah, Nur Ralhan
dc.contributor.authorRowan, Neil J.
dc.identifier.citationUsuldin, S.R. A., Wan-Mohtar, I., Ilham, Z., Jamaludin, A.A., Abdullah, N.R., Rowan, Neil (2021). In-vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian Tiger milk mushroom mycelius for potential future health applications. DOI:
dc.description.abstractNatural mycelial biomass (MB) and exopolysaccharide (EPS) produced from bioreactor-grown Malaysian Tiger Milk Mushroom Lignosus rhinocerus are considered high-end components due to their high commercial potential value in drug discovery. Both MB (0.16-10 mg/mL) and EPS (0.16-10 mg/mL) extracts were tested for Zebrafish Embryo Toxicity (ZFET) and early development effects on Zebrafish Embryos (ZE) during 24-120 h post-fertilization (HPF) in order to assess toxicity given potential application as a new therapy for treating asthma. Finding revealed that MB was deemed to be safe with an LC50 of 0.77 mg/mL; EPS was shown to be non-toxic (LC50 of 0.41 mg/mL). Neither MB nor EPS delayed hatching nor teratogenic defects in treated ZE at a dose of 2.5 mg/mL. There were no significant changes in the ZE heart rate after MB or EPS treatments with MB (0.16-10 mg/mL: 130 beats/min) and EPS (0.16-10 mg/mL: 140 beats/min), as compared to normal ZE (120-180 beats/min). In addition, mixing of both natural compounds MB and EPS did not affect toxicity using ZFET testing; thus, intimating their safe future use as therapeutic interventions.en_US
dc.publisherNature Researchen_US
dc.relation.ispartofScientific Reportsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectMycelial biomassen_US
dc.subjectZebrafish embryo toxicityen_US
dc.titleIn-vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian Tiger milk mushroom mycelius for potential future health applicationsen_US
dc.contributor.affiliationAthlone Institute of Technologyen_US
dc.identifier.orcid 0000-0003-1228-3733en_US
dc.subject.departmentBioscience Research Institute AITen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International