Show simple item record

dc.contributor.authorBandeira, Marina
dc.contributor.authorChee, Bor Shin
dc.contributor.authorFrassini, Rafaele
dc.contributor.authorNugent, Michael
dc.contributor.authorGiovanela, Marcelo
dc.contributor.authorRoesch-Ely, Mariana
dc.contributor.authorda Silva Crespo, Janaina
dc.contributor.authorDevine, Declan M.
dc.date.accessioned2021-06-30T12:54:49Z
dc.date.available2021-06-30T12:54:49Z
dc.date.copyright2021
dc.date.issued2021-05-27
dc.identifier.citation: Bandeira, M.; Chee, B.S.; Frassini, R.; Nugent, M.; Giovanela, M.; Roesch-Ely, M.; Crespo, J.d.S.; Devine, D.M. (2021). Antimicrobial PAA/PAH electrospun fiber containing green synthesized zinc oxide nanoparticles for wound healing. Materials. 14, 2889. https://doi.org/10.3390/ma14112889en_US
dc.identifier.urihttp://research.thea.ie/handle/20.500.12065/3611
dc.description.abstractWound infections are the main complication when treating skin wounds. This work reports a novel antimicrobial material using green synthesized zinc oxide nanoparticles (ZnONPs) incorporated in polymeric fibers for wound healing purposes. ZnONPs are a promising antimicrobial nanomaterial with high activity against a range of microorganisms, including drug-resistant bacteria. The electrospun fibers were obtained using polyacrylic acid (PAA) and polyallylamine hydrochloride (PAH) and were loaded with ZnONPs green synthesized from Ilex paraguariensis leaves with a spherical shape and ~18 nm diameter size. The fibers were produced using the electrospinning technique and SEM images showed a uniform morphology with a diameter of ~230 nm. EDS analysis proved a consistent dispersion of Zn in the fiber mat, however, particle agglomerates with varying sizes were observed. FTIR spectra confirmed the interaction of PAA carboxylic groups with the amine of PAH molecules. Although ZnONPs presented higher antimicrobial activity against S. aureus than E. coli, resazurin viability assay revealed that the PAA/PAH/ZnONPs composite successfully inhibited both bacteria strains growth. Photomicrographs support these results where bacteria clusters were observed only in the control samples. The PAA/PAH/ZnONPs composite developed presents antimicrobial activity and mimics the extracellular matrix morphology of skin tissue, showing potential for wound healing treatments.en_US
dc.formatPDFen_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.ispartofMaterialsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectZinc oxide nanoparticlesen_US
dc.subjectAntimicrobialen_US
dc.subjectElectrospinningen_US
dc.subjectPolymer fiberen_US
dc.subjectWound healingen_US
dc.titleAntimicrobial PAA/PAH electrospun fiber containing green synthesized zinc oxide nanoparticles for wound healingen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.contributor.affiliationAthlone Institute of Technologyen_US
dc.contributor.sponsorCAPES/ CNPqen_US
dc.description.peerreviewyesen_US
dc.identifier.doi10.3390/ma14112889en_US
dc.identifier.eissn1996-1944
dc.identifier.orcidhttps://orcid.org/0000-0003-3739-4421en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1606-1759en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7469-4389en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1364-5583en_US
dc.identifier.volume14en_US
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.departmentMaterials Research Instituteen_US
dc.type.versioninfo:eu-repo/semantics/publishedVersionen_US
dc.relation.projectidPDSE-88881.187620/2018-01 and 88887.153309/2017-00/(426731;2018-2)en_US


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International