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dc.contributor.authorMcEvoy, Brian
dc.contributor.authorRowan, Neil J.
dc.date.accessioned2020-04-24T10:41:43Z
dc.date.available2020-04-24T10:41:43Z
dc.date.copyright2019
dc.date.issued2019-08
dc.identifier.citationMcEvoy, B., Rowan, N.J. (2019). Terminal sterilization of medical devices using vaporized hydrogen peroxide: a review of current methods and emerging opportunities. Journal of Applied Microbiology. 127 (5). doi:10.1111/jam.14412.en_US
dc.identifier.issn1364-5072
dc.identifier.otherArticles - Bioscience Research Institute AITen_US
dc.identifier.urihttp://research.thea.ie/handle/20.500.12065/3116
dc.description.abstractMedical devices are an important and growing aspect of healthcare provision and are increasing in complexity to meet established and emerging patient needs. Terminal sterilization plays a vital role in the provision of safe medical devices. While terminal sterilization technologies for medical devices include multiple radiation options, ethylene oxide remains the predominant nonthermal gaseous option, sterilizing c. 50% of all manufactured devices. Vaporized hydrogen peroxide (abbreviated VH2O2 by the International Organization for Standardization) is currently deployed for clinical sterilization applications, where its performance characteristics appear aligned to requirements, constituting a viable alternative low-temperature process for terminal processing of medical devices. However, VH2O2 has operational limitations that create technical challenges for industrial-scale adoption. This timely review provides a succinct overview of VH2O2 in gaseous sterilization and addresses its applicability for terminal sterilization of medical devices. It also describes underappreciated factors such as the occurrence of nonlinear microbial inactivation kinetic plots that may dictate a need to develop a new standard approach to validate VH2O2 for terminal sterilization of medical devices.en_US
dc.formatPDFen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Microbiology.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ie/*
dc.subjectBacillusen_US
dc.subjectBacterial endosporesen_US
dc.subjectMedical devicesen_US
dc.subjectSterilizationen_US
dc.subjectTerminal gaseousen_US
dc.subjectVaporized hydrogen peroxideen_US
dc.titleTerminal sterilization of medical devices using vaporized hydrogen peroxide: a review of current methods and emerging opportunities.en_US
dc.typeArticleen_US
dc.contributor.sponsorAthlone Institute of Technology Doctoral Funding Programme and STERIS ASTen_US
dc.description.peerreviewyesen_US
dc.identifier.doidoi:10.1111/jam.14412.
dc.identifier.orcidhttps://orcid.org/0000-0003-1228-3733
dc.rights.accessOpen Accessen_US
dc.subject.departmentBioscience Research Instituteen_US


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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland