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dc.contributor.authorde Lima, Gabriel Goetten
dc.contributor.authorDevine, Declan M.
dc.contributor.authorde Alencar, Caroline M.
dc.contributor.authorJunqueira, Amanda
dc.contributor.authorEmanuel, Ramon
dc.contributor.authorNugent, Michael J.D.
dc.date.accessioned2020-04-07T10:33:10Z
dc.date.available2020-04-07T10:33:10Z
dc.date.copyright2014
dc.date.issued2014-05
dc.identifier.citationde Lima, G.G., Devine, D. M., de Alencar, C.M., Junqueira, A., Emanuel, R., Nugent, M.J.D. (2014). Preparation and characterization of novel poly(vinyl) (alcohol) (PVA) and poly(acrylic acid) (PAA) hydrogels for sensitive hydrogels. 1st International Electronic Conference on Materials. 26 May- 10 June 2014. https://sciforum.net/conference/emc-1.en_US
dc.identifier.otherOther - Materials Research Instituteen_US
dc.identifier.urihttp://research.thea.ie/handle/20.500.12065/3083
dc.description.abstractStimuli Sensitive hydrogels have enormous potential in various applications. Various environmental variables are found in the body, such as low pH and elevated temperatures. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. For many applications hydrogels require a very rapid time-response in terms of their sensitivity to either pH and/or temperature. Rapid time-responsive sensitivity is a research field which is still in development. In this research pH-sensitive hydrogels have been made varying the composition and molecular weight of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA). After total dissolution of the PVA/PAA the hydrogel was freeze/thawed. The swelling responses were investigated as well as the drug release profile with varying pH. The drug release was studied with a model drug theophylline. The characteristic properties were examined with ac impedance. The results showed that the optimum formulation to be used as a stimulus sensitive hydrogel is found with lower concentration of PVA and a higher concentration of PAA. These PVA/PAA hydrogels have potential in biomedical applications.en_US
dc.formatPDFen_US
dc.language.isoenen_US
dc.publisherSciforumen_US
dc.relation.ispartof1st International Electronic Conference on Materialsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ie/*
dc.subjectHydrogelsen_US
dc.subjectpH sensitivityen_US
dc.subjectPoly(vinylAlcohol)en_US
dc.subjectFreeze-Thawen_US
dc.titlePreparation and characterization of novel poly(vinyl) (alcohol) (PVA) and poly(acrylic acid) (PAA) hydrogels for sensitive hydrogels.en_US
dc.typeOtheren_US
dc.description.peerreviewyesen_US
dc.identifier.conference1st International Conference on Materials. 26-May -10 June 2014
dc.identifier.orcidhttps://orcid.org/0000-0002-6161-4626
dc.identifier.orcidhttps://orcid.org/0000-0002-1364-5583
dc.identifier.urlhttps://sciforum.net/conference/emc-1
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Instituteen_US


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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland