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dc.contributor.authorSteffens, Luiza
dc.contributor.authorChee, Bor Shin
dc.contributor.authorMoura, Dinara Jacqueline
dc.contributor.authorNugent, Michael
dc.date.accessioned2020-03-30T15:51:02Z
dc.date.available2020-03-30T15:51:02Z
dc.date.copyright2018
dc.date.issued2019-06-13
dc.identifier.citationSteffens, L., Chee, B.S.., Moura, J.M., Nugent, M. (2019). Freeze-thaw electrospun PVA-Dacarbazine nanoparticles: preparation, characterization and anticancer evalution. International Journal of Polymeric Materials and Polymeric Biomaterials. 13 June.https://doi.org/10.1080/00914037.2019.1605606.en_US
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.otherArticles - Materials Research Institute AITen_US
dc.identifier.urihttp://research.thea.ie/handle/20.500.12065/3068
dc.description.abstractDacarbazine (DTIC) is an antitumor agent that has limited clinical applications due to its insolubility, instability and toxicity to normal cells. One possibility to achieve controlled release is PVA-based NPs. This work presents electrospun NPs that combines PVA and DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2 ± 113.6 nm, suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs were effective against glioblastoma cells. This study indicates that the formulated NPs improved DTIC solubility and efficacy.en_US
dc.formatPDFen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Onlineen_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ie/*
dc.subjectElectrospinningen_US
dc.subjectDacarbazineen_US
dc.subjectNanoparticlesen_US
dc.subjectPolyvinyl alcoholen_US
dc.subjectAnticancer activityen_US
dc.subjectFreeze-thawen_US
dc.titleFreeze-thaw electrospun PVA-Dacarbazine nanoparticles: preparation, characterization and anticancer evalution.en_US
dc.typeArticleen_US
dc.description.peerreviewyesen_US
dc.identifier.doihttps://doi.org/10.1080/00914037.2019.1605606
dc.identifier.orcidhttps://orcid.org/0000-0003-1606-1759
dc.identifier.orcidhttps://orcid.org/0000-0002-7469-4389
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Instituteen_US


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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland