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dc.contributor.authorFuenmayor, Evert
dc.contributor.authorForde, Martin
dc.contributor.authorHealy, Andrew V.
dc.contributor.authorDevine, Declan M.
dc.contributor.authorLyons, John G.
dc.contributor.authorMcConville, Christopher
dc.contributor.authorMajor, Ian
dc.identifier.citationFuenmayor, E., Forde, M., Healy, A.V., Devine, D.M., Lyons, J.G., McConville, C., Major, I. (2019). Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets. International Journal of Pharmaceutics. 58: 328-340.
dc.identifier.otherArticles - Materials Research Institute AITen_US
dc.description.abstractOral tablets are a convenient form to deliver active pharmaceutical ingredients (API) and have a high level of acceptance from clinicians and patients. There is a wide range of excipients available for the fabrication of tablets thereby offering a versatile platform for the delivery of therapeutic agents to the gastrointestinal tract. However, the geometry of tablets is limited by conventional manufacturing processes. This study aimed to compare three manufacturing processes in the production of flat-faced oral tablets using the same formulation composed of a polymer blend and caffeine as a model drug: fused-filament fabrication (FFF), direct compression (DC) and injection molding (IM). Hot-melt extrusion was used to convert a powder blend into feedstock material for FFF and IM processes, while DC was performed on the powder mixture. Tablets were produced with the same dimensions and were characterized for their physical and dissolution properties. There were statistical differences in the physical properties and drug release profiles of the tablets produced by the different manufacturing processes. DC tablets displayed immediate release, IM provided sustained release over 48 h, and FFF tablets displayed both release types depending on the printing parameters. FFF continues to demonstrate high potential as a manufacturing process for the efficient production of personalized oral tablets.en_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.subject3D printingen_US
dc.subjectInjection moldingen_US
dc.subjectDirect compressionen_US
dc.subjectHot-melt extrusionen_US
dc.subjectControlled drug releaseen_US
dc.subjectOral tabletsen_US
dc.titleComparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets.en_US
dc.contributor.sponsorAIT President’s Seed Fund grant and funding from the Technological Higher Education Association Ireland.en_US
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Instituteen_US

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland