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dc.contributor.authorWhelehan, Cormac J.
dc.contributor.authorBarry-Reidy, Anne
dc.contributor.authorMeade, Kieran G.
dc.contributor.authorEckersall, P. David
dc.contributor.authorChapwanya, Aspinas
dc.contributor.authorNarciandi, Fernando
dc.contributor.authorLloyd, Andrew T.
dc.contributor.authorO’Farrelly, Cliona
dc.identifier.citationWhelehan, C. J., Barry-Reidy, A., Meade, K. G., Eckersall, P. D., Chapwanya, A., Narciandi, F., . . . O'Farrelly, C. (2014). Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue. BMC Genomics, 15(1). doi:10.1186/1471-2164-15-128en_US
dc.description.abstractBackground Cathelicidins comprise a major group of host-defence peptides. Conserved across a wide range of species, they have several functions related to host defence. Only one cathelicidin has been found in humans but several cathelicidin genes occur in the bovine genome. We propose that these molecules may have a protective role against mastitis. The aim of this study was to characterise the cathelicidin gene-cluster in the bovine genome and to identify sites of expression in the bovine mammary gland. Results Bioinformatic analysis of the bovine genome (BosTau7) revealed seven protein-coding cathelicidin genes, CATHL1-7, including two identical copies of CATHL4, as well as three additional putative cathelicidin genes, all clustered on the long arm of chromosome 22. Six of the seven protein-coding genes were expressed in leukocytes extracted from milk of high somatic cell count (SCC) cows. CATHL5 was expressed across several sites in the mammary gland, but did not increase in response to Staphylococcus aureus infection. Conclusions Here, we characterise the bovine cathelicidin gene cluster and reconcile inconsistencies in the datasets of previous studies. Constitutive cathelicidin expression in the mammary gland suggests a possible role for these host defence peptides its protection.en_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofBMC Genomicsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.subjecthidden Markov model (HMM)en_US
dc.subjectgene clusteren_US
dc.subjecttissue expressionen_US
dc.titleCharacterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissueen_US
dc.contributor.grantnoRSF 06-340en_US
dc.contributor.sponsorDepartment of Agriculture, Fisheries and Food Research Stimulus Fund Granten_US
dc.subject.departmentenviroCORE - IT Carlowen_US

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland