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dc.contributor.authorHurley, Dean
dc.contributor.authorCarter, David
dc.contributor.authorNg, Lawrence Yee Foong
dc.contributor.authorDavis, Mark
dc.contributor.authorWalker, Gavin M.
dc.contributor.authorLyons, John G.
dc.contributor.authorHigginbotham, Clement L.
dc.date.accessioned2020-03-02T12:17:12Z
dc.date.available2020-03-02T12:17:12Z
dc.date.copyright2019
dc.date.issued2019-10
dc.identifier.citationHurley, D., Carter, D., Ng, L.Y.F., Davis, M., Walker, G.M., Lyons, J.G., C.L. Higginbotham. (2019). An investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed Copovidone hot-melt extruded solid dispersions. Journal of Drug Delivery Science and Technology. 53: 101132. https://doi.org/10.1016/j.jddst.2019.101132en_US
dc.identifier.issn1773-2247
dc.identifier.otherArticles - Materials Research Instituteen_US
dc.identifier.urihttp://research.thea.ie/handle/20.500.12065/3022
dc.description.abstractPrevious research has focused on spray dried quaternary mixtures which due to the addition of a surfactant 26 affected the physical stability and amorphous stability of selected model drugs. Very little research has 27 focused on how inter-molecular interactions play a role in the successful formulation of hot-melt extruded 28 quaternary amorphous blends and how they affect physical stability and solubility of amorphous solid 29 dispersions (ASDs). Therefore the aim of this study was to investigate the role of inter-molecular 30 interactions and their effect on the solid-state and dissolution properties of mixed copovidone amorphous 31 solid dispersions (ASDs). The polymeric copovidone carriers used in this study was Poly (vinylpyrrolidone-32 vinyl acetate copolymer) and Plasdone S-630 (PL-S630) which in terms of monographs are the same, 33 however they have different solid-state and dissolution properties. The ASDs showed a significantly higher 34 dissolution rate compared to amorphous and pure INM in pH buffer 1.2 with a kinetic solubility of 24 35 μg/ml. The stability data showed that INM remained amorphous in solid solutions with PVP VA64 and 36 Plasdone S-630, except for the higher drug loads. It was concluded that % drug loading did have a 37 significant effect on the solubility of INM due to recrystallization at higher drug loads.en_US
dc.formatPDFen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ie/*
dc.subjectSolid dispersionen_US
dc.subjectCrystallizationen_US
dc.subjectGlass transitionen_US
dc.subjectExtrusionen_US
dc.subjectSolubilityen_US
dc.subjectAmorphousen_US
dc.titleAn investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed Copovidone hot-melt extruded solid dispersions.en_US
dc.typeArticleen_US
dc.description.peerreviewyesen_US
dc.identifier.doihttps://doi.org/10.1016/j.jddst.2019.101132
dc.identifier.orcidhttps://orcid.org/0000-0002-7629-4063
dc.identifier.orcidhttps://orcid.org/0000-0003-1998-070X
dc.identifier.orcidhttps://orcid.org/0000-0001-8100-6276
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute - AITen_US


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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland