Show simple item record

dc.contributor.authorDevine, Declan M.
dc.contributor.authorHigginbotham, Clement
dc.contributor.authorGeever, Luke M.
dc.contributor.authorCoffey, Conor
dc.identifier.citationCoffey, C., Devine, D., Higginbotham, C., and Geever, L. (2018). Enhancing the bioavailability of hydrophobic drugs using hot melt extrusion. [Poster]. Exhibited at AIT Research Day.en_US
dc.identifier.otherOthers - Materials Research Institute - AITen_US
dc.description.abstractMany existing drugs (as well as new revelations) in the pharmaceutical industry bear a distinct disadvantage in the sense that they are not water soluble, displaying low bioavailability values and consequently a reduced invitro effect. Hot melt extrusion (HME) is one technique currently being used to increase the solubility of hydrophobic compounds. The current study examined the feasibility of enhancing the bioavailability of poorly soluble veterinary anthelmintics using melt extrusion. It was demonstrated that melt extrusion changed the morphology of the API,converting it from a crystalline (insoluble) to an amorphous (soluble) state. Subsequent dissolution trials demonstrated the concept dosage forms to greatly enhance the solubility of the API.en_US
dc.publisherAthlone Institute of Technologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.subjectHot melt extrusion
dc.subjectHydrophobic veterinary anthelmintics
dc.subjectManufacturing processes
dc.subjectHydrophobic compounds
dc.subjectMaterials engineering
dc.titleEnhancing the bioavailability of hydrophobic drugs using hot melt extrusionen_US
dc.identifier.conferenceAIT Research Presentations & Posters Conference. Athlone Institute of Technology 24th April 2018
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Instituteen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland