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dc.contributor.authorde Sousa Seguno, Francisco Alipio
dc.contributor.authorde Sousa Costa, Edla Iris
dc.contributor.authorSantos de Azevedo, Adílio
dc.contributor.authorLucélia de Araújuo, Ana
dc.contributor.authorde França Silva, Ana Clara
dc.contributor.authorGoetten de Lima, Gabriel
dc.contributor.authorCavalcanti de Sá, Marcelo Jorge
dc.date.accessioned2019-10-07T11:00:39Z
dc.date.available2019-10-07T11:00:39Z
dc.date.copyright2018
dc.date.issued2018-06
dc.identifier.citationde Sousa Seguno, F.,de Sousa Costa, E., Santos de Azevedo, A., Lucélia de Araújuo, A., de França Silva, A., Goetten de Lima, G.,Cavalcanti de Sá, M. (2018). Platelet-rich plasma, Hydroxyapatite, and Chitosan in the bone and cartilaginous regeneration of femoral trochlea in rabbits: clinical, radiographic, and histomorphometric evaluations. Journal of Healthcare Engineering. (9), 1-6. doi: 10.1155/2018/6917958en_US
dc.identifier.otherArticles - Materials Research Instituteen_US
dc.identifier.urihttp://research.thea.ie/handle/20.500.12065/2817
dc.description.abstractThe aim of this study was to evaluate the trochlear bone and cartilaginous regeneration of rabbits using the association of PRP, chitosan, and hydroxyapatite. Hole was made in rabbit troches, one hole in each animal remained empty (group C), and one was filled by a combination of PRP, chitosan, and hydroxyapatite (group T). Clinical-orthopedic, radiographic, and histomorphometric evaluations were performed. Clinical-orthopedic evaluation showed lameness of two members of the Tgroup and one member of group C. *e radiographic evaluation showed that the T group showed absence of subchondral bone reaction (33%). *e presence of moderate subchondral bone reaction was more frequently reported in group C with 67%. Microscopic evaluation revealed a presence of tissue neoformation, composed of connective tissue. Microscopic findings were similar in both groups, with a difference in the amount of neoformed tissue being perceptible, which was confirmed after the morphometric analysis, which revealed a significant difference in the quantity of newly formed tissue at the bone/cartilage/implant interface. The composite base of the association of chitosan, hydroxyapatite, and platelet-rich plasma favored bone and cartilage healing.en_US
dc.formatPDFen_US
dc.language.isoenen_US
dc.publisherHindawien_US
dc.relation.ispartofJournal of Healthcare Engineeringen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ie/*
dc.subjectBone regenerationen_US
dc.subjectTissue engineeringen_US
dc.titlePlatelet-rich plasma, Hydroxyapatite, and Chitosan in the bone and cartilaginous regeneration of femoral trochlea in rabbits: clinical, radiographic, and histomorphometric evaluations.en_US
dc.typeArticleen_US
dc.description.peerreviewyesen_US
dc.identifier.doioi: 10.1155/2018/6917958
dc.identifier.orcidhttps://orcid.org/0000-0002-6161-4626
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute AITen_US


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