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dc.contributor.authorNugent, Michael J.
dc.contributor.authorHanley, A.
dc.contributor.authorTomkins, P.T.
dc.contributor.authorHigginbotham, C.L.
dc.identifier.citationNugent, M.J.D., Hanley, A., Tomkins, P.T., Higginbotham. C.L. (2005). Investigation of a novel freeze-thaw process for the production of drug delivery hydrogels. Journal of Materials Science. Materials in Medicine. v.16 (12): 1149-1158. doi: 10.1007/s10856-005-4722-7en_US
dc.identifier.otherArticles - Materials Research Instituteen_US
dc.description.abstractPoly(vinyl alcohol) (PVA) is a water-soluble, biocompatible and biodegradable polymer, which has been widely applied in biomedical fields. In this paper, novel physically cross-linked hydrogels composed of PVA and comprising a blend of poly(vinyl alcohol) (PVA) with different concentrations of HCl, NaOH and NaCl are prepared by a freezing/thawing treatment of aqueous solutions. The structure and complexation of the electrolytes were studied by Fourier transform infrared (FTIR) spectroscopy. The mechanical properties were investigated using rheometery and the thermal transitions of the hydrogels were examined by modulated differential scanning calorimetry (MDSC). Freeze/thawed PVA gels containing NaOH showed overall enhanced swelling with increased mechanical strength over traditional gels prepared by chemical or irradiative crosslinking techniques. These novel physically cross-linked hydrogels show promise for a variety of biomedical and drug delivery applications.en_US
dc.relation.ispartofJournal of Materials Science. Materials in Medicine.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.subjectFreeze-thaw cycleen_US
dc.subjectDrug delivery systemsen_US
dc.titleInvestigation of a novel freeze-thaw process for the production of drug delivery hydrogelsen_US
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute AITen_US

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland