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dc.contributor.authorNugent, Michael J.
dc.contributor.authorHigginbotham, Clement L.
dc.date.accessioned2019-09-30T08:48:56Z
dc.date.available2019-09-30T08:48:56Z
dc.date.copyright2007
dc.date.issued2007-09
dc.identifier.citationNugent, M., Higginbotham, C.L. (2007). Preparation of a novel freeze thawed Poly (vinyl alcohol) composite hydrogel for drug delivery applications. European Journal of Pharmaceutics and Biopharmaceutics. v.67 (2), September, 377-386. https://doi.org/10.1016/j.ejpb.2007.02.014en_US
dc.identifier.issn0939-6411
dc.identifier.otherArticles - Materials Research Instituteen_US
dc.identifier.urihttp://research.thea.ie/handle/20.500.12065/2813
dc.description.abstractPoly(vinyl alcohol) (PVA) is a water-soluble, biocompatible and biodegradable polymer, which has been widely applied in biomedical fields. In this paper, novel physically cross-linked hydrogels composed of PVA and comprising a blend of poly(vinyl alcohol) (PVA) with different concentrations of HCl, NaOH and NaCl are prepared by a freezing/thawing treatment of aqueous solutions. The structure and complexation of the electrolytes were studied by Fourier transform infrared (FTIR) spectroscopy. The mechanical properties were investigated using rheometery and the thermal transitions of the hydrogels were examined by modulated differential scanning calorimetry (MDSC). Freeze/thawed PVA gels containing NaOH showed overall enhanced swelling with increased mechanical strength over traditional gels prepared by chemical or irradiative crosslinking techniques. These novel physically cross-linked hydrogels show promise for a variety of biomedical and drug delivery applications.en_US
dc.formatPDFen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Pharmaceutics and Biopharmaceuticsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ie/*
dc.subjectPolymer compositesen_US
dc.subjectDrug delivery systemsen_US
dc.subjectHydrogelsen_US
dc.subjectRheometryen_US
dc.subjectFreeze-thaw cycleen_US
dc.titlePreparation of a novel freeze thawed poly (vinly alcohol) composite hydrogel for drug delivery applicationsen_US
dc.typeArticleen_US
dc.description.peerreviewyesen_US
dc.identifier.doihttps://doi.org/10.1016/j.ejpb.2007.02.014
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute AITen_US


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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland