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dc.contributor.authorde Lima, Gabriel Goetten
dc.contributor.authorChee, Bor Shin
dc.contributor.authorMoritz, Vicente Froés
dc.contributor.authorCortese, Yvonne J.
dc.contributor.authorMaghalhães, Washington L. E.
dc.contributor.authorDevine, Declan M.
dc.contributor.authorNugent, Michael J. D.
dc.date.accessioned2019-06-18T14:36:03Z
dc.date.available2019-06-18T14:36:03Z
dc.date.copyright2019
dc.date.issued2019-06-05
dc.identifier.citationGoetten de Lima, G., Chee, B.S., Moritz, V. F., Magalhães, W.L.E., Devine, D. M.,Nugent, M.J.D., (2019).The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system. Biomedical Physics & Engineering Express, v.5, 045017en_US
dc.identifier.issn2057-1976
dc.identifier.otherMaterials Research Institute AIT - Articlesen_US
dc.identifier.urihttp://research.thea.ie/handle/20.500.12065/2738
dc.description.abstractAlthough freeze-thaw mechanism for producing crosslinked hydrogels is relatively easy and simple, it lacks sufficient integrity and support leading to modifications on its three-dimensional polymeric network arrangement during water removal—drying. Therefore, a strengthening method for obtaining cryogenic spheres of polyvinyl alcohol hydrogels is purposed by dispensing it as liquid droplets into a low temperature solution followed by a modification on its freeze-thaw cycles to confer a good geometry without aggregation. Various materials were incorporated into this hydrogel structure, including poly(acrylic acid) to impart pH sensitivity; hydroxyapatite to improve biocompatibility; and ciprofloxacin as an antimicrobial agent relevant for the treatment of osteomyelitis. The overall network presented a porous structure with a fibrous-like pattern which varied in size and volume, with presence of Ca and P when hydroxyapatite is incorporated. These materials varied the crystalline melting point of the poly(vinyl alcohol) and a linear pHsensitivity function was obtained by the addition of the materials. These hydrogels were found to release ciprofloxacin within 60 min and were able to dissolve at the same time intervals. Therefore, the hydrogel synthesised in this work can be used as an immediate release drug delivery mechanism for the in situ delivery of active pharmaceutical such as ciprofloxacin for a treatment of osteomyelitis.en_US
dc.formatPDFen_US
dc.language.isoenen_US
dc.publisherIOP Scienceen_US
dc.relation.ispartofBiomedical Physics & Engineering Expressen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ie/*
dc.subjectDrug delivery systemsen_US
dc.subjectOral drug deliveryen_US
dc.subjectPolyvinyl alcoholen_US
dc.subjectBiomedicineen_US
dc.titleThe production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system.en_US
dc.typeArticleen_US
dc.identifier.doihttps://orcid.org/0000-0002-1364-5583
dc.identifier.doidoi: 10.1088/2057-1976/ab2547
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute AITen_US


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