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dc.contributor.authorChee, Bor Shin
dc.contributor.authorde Lima, Gabriel Goetten
dc.contributor.authorDevine, Declan M.
dc.contributor.authorNugent, Michael J. D.
dc.identifier.citationChee, B.S., de Lima, G.G., Devine, D., Nugent, M.J.D. (2018). Investigation of the effects of orientation on freeze/thawed Polyvinyl alcohol hydrogel properties. Materials Today Communications, v.17, pp.82.93.
dc.identifier.otherMaterials Research Institute AIT - Articlesen_US
dc.description.abstractAlthough hydrogels produced via freeze-thawing (F/T) technique have been thoroughly studied in literature, stretching hydrogels in between freeze-thawing cycles could change its properties and might be modulated for drug delivery systems. The PVA hydrogels and Caffeine-contained PVA hydrogels were created by freezing for 20 minutes using liquid nitrogen and 4 hours thawing at 4° C. The results revealed that the PVA/CAF hydrogel with two F/T cycles followed by two stretching (S) cycles delivered the best response. Furthermore, this sample had the highest crystallinity degree and Young’s modulus of 36 % and 1462 MPa, respectively, which makes this hydrogel very stiff in comparison to all other samples. Moreover, it fits in the Hixson-Crowell drug release model with the fastest drug releasing rate, 15 minutes, and the highest swelling degree of 470 %. Therefore, the study suggests that the number of F/T cycles and stretching cycles influences the properties of the resulting hydrogels and the caffeine release rate.en_US
dc.relation.ispartofMaterials Today Communicationen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.subjectFreeze-thaw cycleen_US
dc.subjectPolyvinyl alcoholen_US
dc.subjectDrug delivery systemsen_US
dc.titleInvestigation of the effects of orientation on freeze/thawed Polyvinyl alcohol hydrogel properties.en_US
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute AITen_US

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