Show simple item record

dc.contributor.authorde Lima, Gabriel Goetten
dc.contributor.authorde Souza, Ronaldo O,
dc.contributor.authorBozzi, Aline
dc.contributor.authorPoplawska, Malgorzata A.
dc.contributor.authorDevine, Declan M.
dc.contributor.authorNugent, Michael J. D.
dc.identifier.citationde Lima, G. G., de Souza, R. O., Borzzi, A D., Poplawska, M. A., Devine, D.M., Nugent, M.J.D. (2016). Extraction method plays critical role in antibacterial activity of propolis loaded hydrogels. Journal of Pharmaceutical Sciences. v.106 (3), 1248-1257.en_US
dc.identifier.otherMaterials Research Institute AIT - Articlesen_US
dc.description.abstractExtracted propolis has been used for a long time as a remedy. However, if the release rate of propolis is not controlled, the efficacy is reduced. To overcome this issue, extracted propolis was added to a cryogel system. Propolis collected from southern Brazil was extracted using different methods and loaded at different concentrations into polyvinyl alcohol (PVA) and polyacrylic acid hydrogels as carrier systems. The material properties were investigated with a focus on the propolis release profiles and the cryogel antibacterial properties against 4 different bacteria, namely: Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, and Pseudomonas putida. Swelling studies indicated that the swelling of the hydrogel was inversely related to propolis content. In addition, propolis release studies indicated a decreased release rate with increased propolis loading. PVA and PVA/polyacrylic acid–loaded propolis were effective against all 4 bacteria studied. These results indicate that the efficacy of propolis can be enhanced by incorporation into hydrogel carrier systems and that hydrogels with higher concentrations of propolis can be considered for use as bactericide dressing.en_US
dc.relation.ispartofJournal of Pharmaceutical Sciencesen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.subjectPolymer synthesisen_US
dc.subjectPolymer materialsen_US
dc.subjectPolymeric drug delivery systemsen_US
dc.titleExtraction method plays critical role in antibacterial activity of propolis loaded hydrogels.en_US
dc.identifier.doidoi: 10.1016/j.xphs.2015.12.027.
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute AITen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland