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dc.contributor.authorCanillas, María
dc.contributor.authorGeever, Tess
dc.contributor.authorVieira, Katilayne
dc.contributor.authorNugent, Michael J. D.
dc.contributor.authorKillion, John
dc.contributor.authorDevine, Declan M.
dc.contributor.authorRodriguez, Miguel A.
dc.identifier.citationCanillas, M., Geever, T., Vieira, Katilayne., Nugent, M.D.; Devine, D.M., Rodriguez, M.A. (2019) Photopolymerization for filling porous ceramic matrix: improvement of mechanical properties and drug delivering behaviour. Polymer Compsites. v.40 (4), pp.1654-1662.
dc.identifier.otherMaterials Research Institute AIT - Articlesen_US
dc.description.abstractThis work presents the photopolymerisation of composite scaffolds where a prefabricated ceramic scaffold was impregnated with poly(ethylene) glycol dimethacrylate (PEGDMA) macromonomer solution. The PEGDMA solution penetrates the porosity of ceramic scaffold where it cures in situ thereby enhancing their mechanical properties. The mechanical properties of the obtained composite approximate the mechanical properties of cancellous bone. The Young´s Modulus of the composite developed is 106 ± 5 MPa. PEGDMA is a polymer that shows excellent percentages of gel fraction (96%), which preserves when ceramic scaffold is introduced, and swelling (134%). Furthermore, thanks to their swelling properties, the composite is able to control the release vancomycin and dexamethasone. The efficacy of in situ delivery of vancomycin is demonstrated by the inhibition of bacteria colony proliferation. Dexamethasone released is recorded for up to 10 days using ultra violet‐visible spectroscopy. These excellent results make photopolymerization and PEGDMA strong candidates for the manufacture of different loaded bone void fillers.en_US
dc.relation.ispartofPolymer Compositesen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.subjectBone regenerationen_US
dc.subjectPolymer compositesen_US
dc.subjectTissue engineeringen_US
dc.titlePhotopolymerization for filling porous ceramic matrix: improvement of mechanical properties and drug delivering behaviour.en_US
dc.title.alternativeHydrogels filling ceramic scaffolds by photopolymerizationen_US
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute AITen_US

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland