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dc.contributor.authorMorris, Noreen
dc.contributor.authorRazak, Fashli
dc.contributor.authorKennedy, James
dc.contributor.authorMurphy, Alan
dc.date.accessioned2019-05-13T08:59:19Z
dc.date.available2019-05-13T08:59:19Z
dc.date.copyright2017
dc.date.issued2017-11
dc.identifier.citationMorris, N., Razak, F., Murphy, A., Kennedy, J., Murphy, A. (2017). Development of Amoxicillin loaded microspheres for anti-Helicobacter pylori infection using Ionic Gelation method. International Journal of Advance Scientific Research and Management. v.2 (11), November, pp.56-67.en_US
dc.identifier.issn2455-6378
dc.identifier.otherMaterials Research Institute AIT - Articlesen_US
dc.identifier.urihttps://research.thea.ie/handle/20.500.12065/2686
dc.description.abstractThe aim of this project was to develop microspheres loaded with Amoxicillin for anti-Helicobacter pylori infection. Amoxicillin loaded microspheres were developed using blends of natural polymers such as Alginate and Chitosan using an Ionotropic gelation method. In this study, the physiochemical properties such as particle size, surface morphology, production yield, drug loading, entrapment efficiency, swelling index, and in vitro drug release mechanism were analysed. From this study, it was found out that AMX06 had the highest particle size (653μm) and drug loading (68%) while AMX01 had the highest production yield and entrapment efficiency (80%). All formulations demonstrated a burst drug release profile and AMX04 provided the best drug release profile (89%) after 6 hours. The FTIR analysis proved that a reaction had been established between the materials with the presence of a peak at 1772 cm-1 indicating the presence of a β-lactam ring of Amoxicillin and peak at 1580 cm-1 indicates the N-H bending of Chitosan amino group.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherIJASRMen_US
dc.relation.ispartofInternational Journal of Advance Scientific Research and Managementen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ie/*
dc.subjectAmoxicillinen_US
dc.subjectChitosanen_US
dc.subjectAlginateen_US
dc.subjectMicrosphereen_US
dc.subjectPolymers in medicineen_US
dc.titleDevelopment of Amoxicillin loaded microspheres for anti-Helicobacter pylori infection using Ionic Gelation methoden_US
dc.typeArticleen_US
dc.description.peerreviewyesen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5892-1441
dc.rights.accessOpen Accessen_US
dc.subject.departmentMaterials Research Institute AITen_US


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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland