Bone is the second most frequently transplanted tissue in humans. There are 2.2 million
bone graft procedures annually, which have several disadvantages such as: donor site morbidity, risk of
disease transmission and a limited supply of bone. While several bone substitute materials exist, none
fulfil all the requirements of an ideal bone substitute material, which should mimic as closely as
possible natural bone. Therefore, the aim of this study was to develop a multifunctional nanocomposite
scaffold for use in bone tissue engineering which prevents antimicrobial attachment.