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The production of solid dosage forms from non-degradable polymers.
(Bentham Science, 2015)
Non-degradable polymers have an important function in medicine. Solid dosage forms for longer term implantation require to be constructed from materials that will not degrade or erode over time and also offer the utmost ...
Mass-customization of oral tablets via the combination of 3D printing and injection molding.
(Elsevier, 2019-10-05)
The new frontier of medicine is the personalization of treatment to match a patient’s individual needs. Fused-filament fabrication (FFF) offers a platform for the personalization of drug dosage forms, but one of its chief ...
Formulation and evaluation of Fenbendazole extended-release extrudes processed by hot-melt extrusion
(MDPI, 2022-10-06)
This study aimed to demonstrate the feasibility of hot-melt extrusion in the development of
extended-release formulations of Fenbendazole (Fen) dispersed in PEO/PCL blend-based matrices.
Their thermal, physical, chemical ...
Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble Indomethacin with Poly(vinyl pyrrolidone-co-vinyl acetate) and polyethylene oxide.
(Elsevier, 2019-08)
This investigation aims to evaluate the effect of moisture and temperature on the physical
stability and dissolution behaviour of hot-melt extruded binary and plasticised ternary solid
dispersions. Poorly water-soluble ...
Material considerations for fused-filament fabrication of solid dosage forms.
(MDPI, 2018-04-02)
Material choice is a fundamental consideration when it comes to designing a solid dosage form. The matrix material will ultimately determine the rate of drug release since the physical properties (solubility, viscosity, ...
Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets.
(Elsevier, 2019-03-10)
Oral tablets are a convenient form to deliver active pharmaceutical ingredients (API) and have a high level of acceptance from clinicians and patients. There is a wide range of excipients available for the fabrication of ...
Micro-injection mouding of PEO/PCL blend-based matrices for extended oral delivery of Fenbendazole
(MDPI, 2023-03-10)
Fenbendazole (FBZ) is a broad-spectrum anthelmintic administered orally to ruminants;
nevertheless, its poor water solubility has been the main limitation to reaching satisfactory and
sustained levels at the site of the ...