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Composite cryogels for dual drug delivery and enhanced mechanical properties.
(Wiley, 2018-04)
In this study, we present a simple and effective process that integrates hydrogels with drugs + ceramics via physical crosslinks resulting in improved mechanical properties. These cryogels have the potential for controlled ...
Micro-injection moulding of poly(vinylpyrrolidone-vinyl acetate) binary and ternary amorphous solid dispersions.
(MDPI, 2019-05)
Micro-injection moulding (µIM) was used for the production of enteric tablets of plasticised
and unplasticised solid dispersions of poly(vinylpyrrolidone-vinyl acetate) (PVPVA), and the effect
of the mechanical and thermal ...
Faster release of lumen-loaded drugs than matrix-loaded equivalent in polylactic acid/halloysite nanotubes.
(MDPI, 2019-06-15)
Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based ...
Investigation of the effects of orientation on freeze/thawed Polyvinyl alcohol hydrogel properties.
(Elsevier, 2018-12)
Although hydrogels produced via freeze-thawing (F/T) technique have been thoroughly studied in literature, stretching hydrogels in between freeze-thawing cycles could change its properties and might be modulated for drug ...
Processing stability and the significance of variation in extrusion speeds and temperture on SSB® 55 Pharma Grade Shellac for Oral Drug Delivery
(MDPI, 2017-09-06)
The melt-extrusion process is utilized in the pharmaceutical arena for the manufacturing of a variety of dosage forms and formulations, including solid dispersions. This technology is considered an efficient and continuous ...
Investigation of a novel freeze-thaw process for the production of drug delivery hydrogels
(Springer, 2005-12)
Poly(vinyl alcohol) (PVA) is a water-soluble, biocompatible and biodegradable polymer, which has been widely applied in biomedical fields. In this paper, novel physically cross-linked hydrogels composed of PVA and comprising ...
The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system.
(IOP Science, 2019-06-05)
Although freeze-thaw mechanism for producing crosslinked hydrogels is relatively easy and simple, it
lacks sufficient integrity and support leading to modifications on its three-dimensional polymeric
network arrangement ...
Preparation of a novel freeze thawed poly (vinly alcohol) composite hydrogel for drug delivery applications
(Elsevier, 2007-09)
Poly(vinyl alcohol) (PVA) is a water-soluble, biocompatible and biodegradable polymer, which has been widely applied in biomedical fields. In this paper, novel physically cross-linked hydrogels composed of PVA and comprising ...
Synthesis and characterisation of novel temperature and pH sensitive physically crosslinked poly(N-vinylcaprolactam-co-itaconic acid) hydrogels for drug delivery.
(MDPI, 2019-08-29)
Previous studies involving poly N-vinylcaprolactam (PNVCL) and itaconic acid (IA) have synthesised the hydrogels with the presence of a solvent and a crosslinker, producing chemically crosslinked hydrogel systems. In this ...
Novel polyvinyl-alcohol microsphere for everolimus delivery for subependymal cell astrocytoma
(Elsevier, 2023-02-02)
Everolimus (EVR) has demonstrated efficacy in treating subependymal giant cell astrocytoma (SEGA) and other
tuberous sclerosis (TSC) manifestations. Oral use of EVR is associated with low bioavailability and systemic
toxicities ...