Browsing Articles - Department of Pharmaceutical Sciences and Biotechnology by Subject "Faculty of Science and Health"
Now showing items 1-20 of 21
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Accelerated solvent based extraction and enrichment of selected plasticisers and 4-nonylphenol, and extraction of tin from organotin sources in sediments, sludges and leachate soils.
(Elsevier, 2009-02-23)Enrichment techniques have become an important feature in the trace analysis of oestrogen mimicking chemicals in the environment. Recent developments such as accelerated solvent extraction (ASE) have improved extraction ... -
Advanced therapies and the outer limits of DNA regulation: new horizons for patents or a scaffold too far?
(Oxford Academic, 2008-04)This Regulation seeks to regulate existing and future advanced therapy medicinal products intended for the market in Member States, being either prepared industrially or manufactured by a method involving an industrial ... -
Analysis of bio-obtainable endocrine disrupting metals in river water and sediment, sewage influent/effluent, sludge, leachate, and concentrated leachate, in the Irish Midlands Shannon catchment.
(Hindawi, 2009-12)The application of an acid digestion and subsequent solid-phase extraction (SPE) procedure were implemented as preliminary treatments prior to quantifying the levels of potentially endocrine disrupting metals (EDMs) in a ... -
Analytical characterization and pharmacological evaluation of the new psychoactive substance 4-fluoromethylphenidate (4F-MPH) and differentiation between the (±)-threo- and (±)-erythro- diastereomers
(Wiley, 2017-03)Misuse of (±)-threo-methylphenidate (methyl-2-phenyl-2-(piperidin-2-yl)acetate; Ritalin®; MPH) has long been acknowledged, but the appearance of MPH analogs in the form of 'research chemicals' has only emerged in more ... -
Characterisation of biopharmaceuticals
(The Institute of Chemistry of Ireland, 2016-07)Biopharmaceuticals are drugs which are primarily (glyco)protein in nature, that are produced in living cells using recombinant DNA technology – the combination of genetic material from multiple sources, creating sequences ... -
Detection, toxicology, environmental fate and risk assessment of nanoparticles in the aquatic environment (DeTER)
(EPA, 2018)Nanotechnology is an emerging technology that has the potential to impact on all aspects of life and the economy and is expected to form the basis of several technological innovations and advances in the 21st century. ... -
Fluorinated phenmetrazine “legal highs” act as substrates for high-affinity monoamine transporters of the SLC6 family.
(Elsevier, 2018-05-15)A variety of new psychoactive substances (NPS) are appearing in recreational drug markets worldwide. NPS are compounds that target various receptors and transporters in the central nervous system to achieve their ... -
Investigations on the efficacy of routinely used phenotypic methods compared to genotypic approaches for the identification of staphylococcal species isolated from companion animals in Irish veterinary hospitals
(BMC, 2013)BACKGROUND: Identification of Staphylococci to species level in veterinary microbiology is important to inform therapeutic intervention and management. We report on the efficacy of three routinely used commercial phenotypic ... -
Isocractic LC methods for the trace analysis of phthalates and 4-nonylphenol in varying types of landfill and adjacent run-offs.
(Taylor & Francis Online, 2007-07)To determine the levels of known endocrine disrupting chemicals such as phthalates and alkylphenols in environmental samples such as leachate water and sediment, suitable isocratic high performance liquid chromatographic ... -
A laboratory investigation of the antimicrobial activity of a selection of western phytomedicinal tinctures.
(Elsevier, 2018-04)Introduction: Following the observed success of a herbal cocktail in controlling and eliminating acute respiratory infections in a group of approximately sixty, 1–3 year old equines, it was decided to test ten of the herbs ... -
Microbiological degradation of pesticides in yard waste composting.
(American Society for Microbiology, 1991)Changes in public opinion and legislation have led to the general recognition that solid waste treatment practices must be changed. Solid-waste disposal by landfill is becoming increasingly expensive and regulated and no ... -
Natural and synthetic isothiocyanates possess anticancer potential against liver and prostate cancer in vitro.
(International Institute of Anticancer Research, 2019-07)Background/Aim: Isothiocyanates (ITCs) are phytochemicals with potential cancer-preventative properties derived from the breakdown of glucosinolates that exist in cruciferous vegetables. Studies, to date, have ... -
Prediction of toxigenic fungal growth in buildings by using a novel modelling system.
(American Society for Microbiology, 1999-11)There is growing concern about the adverse effects of fungal bioaerosols on the occupants of damp dwellings. Based on an extensive analysis of previously published data and on experiments carried out within this ... -
Preparation and characterization of the ‘research chemical’ diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers.
(Wiley, 2015-05)Substances with the diphenylethylamine nucleus represent a recent addition to the product catalog of dissociative agents sold as research chemicals on the Internet. Diphenidine, i.e. 1-(1,2-diphenylethyl)piperidine ... -
Pulsed-light reduces the toxicity of the algal toxin okadaic acid to freshwater crustacean Daphnia pulex.
(Springer, 2018-01)This constitutes the first study to report on the reduction in toxicity of the dinoflagellate algal toxin okadaic acid after novel pulsed light (PL) treatments where ecotoxicological assessment was performed using a ... -
The synthesis and characterization of the ‘research chemical’ N-(1- amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl) -1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer.
(Wiley, 2016-09)This study presents the identification of N-(1-amino-3-methyl-1-oxobutan-2-yl)-1- (cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide that was termed 3,5-AB-CHMFUPPYCA. This compound was obtained from a ... -
Synthesis, analytical characterization and monoamine transporter activity of the new psychoactive substance 4- methylphenmetrazine (4-MPM), with differentiation from its ortho- and meta- positional isomers
(Wiley, 2018-09)The availability of new psychoactive substances on the recreational drug market continues to create challenges for scientists in the forensic, clinical and toxicology fields. Phenmetrazine (3-methyl-2-phenylmorpholine) ... -
Synthesis, characterization and monoamine transporter activity of the new psychoactive substance 3’,4’-methylenedioxy-4-methylaminorex (MDMAR).
(Wiley, 2015-07)The recent occurrence of deaths associated with the psychostimulant cis-4,4'-dimethylaminorex (4,4'-DMAR) in Europe indicated the presence of a newly emerged psychoactive substance on the market. Subsequently, the existence ... -
Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone.
(Wiley, 2017-03)3-Methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one (mexedrone) appeared in 2015 and was advertised by UK Internet retailers as a noncontrolled mephedrone derivative (2-(methylamino)-1-(4- methylphenyl)propan-1-one), ... -
Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers
(Wiley, 2017-03)The knowledge captured in patent and scientific research literature stimulates new ideas and fosters new drug development efforts. Manufacturers and entrepreneurs dedicated to the sale of ‘research chemicals’ and/or ...