Browsing Articles - Department of Pharmaceutical Sciences and Biotechnology by Author "Howard, Dawn J."
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DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.
Magee, David A.; Sikora, Klaudia M.; Berowicz, Erik W.; Berry, Donagh P.; Howard, Dawn J.; Mullen, Michael P.; Evans, Ross D.; Spillane, Charles; MacHugh, David E. (BMC, 2010-10-13)Background: Studies in mice and humans have shown that imprinted genes, whereby expression from one of the two parentally inherited alleles is attenuated or completely silenced, have a major effect on mammalian ... -
Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecXG, FecXB) and GDF9 (FecGH) in Belclare and Cambridge sheep.
Mullen, Michael P.; Hanrahan, James P.; Howard, Dawn J.; Powell, Richard (PLOS, 2013-01)This paper concerns the likely origin of three mutations with large effects on ovulation rate identified in the Belclare and Cambridge sheep breeds; two in the BMP15 gene (FecXG and FecXB) and the third (FecGH) in GDF9. ... -
Polymorphism discovery and allele frequency estimation using high-throughput DNA sequencing of target-enriched pooled DNA samples
Mullen, Michael P.; Creevey, Christopher J.; Berry, Donagh P.; McCabe, Matt S.; Magee, David A.; Howard, Dawn J.; Killeen, Aideen P.; Park, Stephen D.; McGettigan, Paul A.; Lucy, Matt C.; MacHugh, David E.; Waters, Sinead M. (BMC, 2012-01-11)Background: The central role of the somatotrophic axis in animal post-natal growth, development and fertility is well established. Therefore, the identification of genetic variants affecting quantitative traits within ... -
Single nucleotide polymorphisms in the growth hormone and insulin-like growth factor-1 genes are associated with milk production, body condition score and fertility traits in dairy cows.
Mullen, Michael P.; Lynch, C.O.; Waters, S.M.; Howard, Dawn J.; O'Boyle, P.; Kenny, D.A.; Buckley, F.; Horan, B.; Diskin, M.G. (GMR, 2011-08-26)The somatotrophic axis (GH-IGF) is a key regulator of animal growth and development, affecting performance traits that include milk production, growth rate, body composition, and fertility. The aim of this study was to ...