Browsing Articles - Department of Pharmaceutical Sciences and Biotechnology by Author "Dillon, Gerald P."
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Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
Dillon, Gerald P.; Gaynor, Joanne M.; Khan, Denise; Carolan, Ciaran G.; Ryder, Sheila A.; Marquez, Juan F.; Reidy, Sean; Gilmer, John F. (Elsevier, 2010-02-01)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer’s Disease (AD). They are stable in human plasma but in mouse plasma they ...