Browsing Articles - Department of Pharmaceutical Sciences and Biotechnology by Author "Brandt, Simon D."
Now showing items 1-7 of 7
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Analytical characterization and pharmacological evaluation of the new psychoactive substance 4-fluoromethylphenidate (4F-MPH) and differentiation between the (±)-threo- and (±)-erythro- diastereomers
Morris, Noreen; McLaughlin, Gavin; Kavanagh, Pierce V.; Power, John D.; Dowling, Geraldine; Twamley, Brendan; O'Brien, Brendan; O'Brien, John; Hessman, Gary; Murphy, Brian; Walther, Donna; Partilla, John S.; Baumann, Michael H.; Brandt, Simon D. (Wiley, 2017-03)Misuse of (±)-threo-methylphenidate (methyl-2-phenyl-2-(piperidin-2-yl)acetate; Ritalin®; MPH) has long been acknowledged, but the appearance of MPH analogs in the form of 'research chemicals' has only emerged in more ... -
Fluorinated phenmetrazine “legal highs” act as substrates for high-affinity monoamine transporters of the SLC6 family.
Mayer, Felix P.; Burchardt, Nadine V.; Decker, Ann M.; Partilla, John S.; Li, Yang; McLaughlin, Gavin; Kavanagh, Pierce V.; Sandtner, Walter; Blough, Bruce E.; Brandt, Simon D.; Baumann, Michael H.; Sitte, Harald H. (Elsevier, 2018-05-15)A variety of new psychoactive substances (NPS) are appearing in recreational drug markets worldwide. NPS are compounds that target various receptors and transporters in the central nervous system to achieve their ... -
In vitro metabolism of the synthetic cannabinoid 3,5‐AB‐CHMFUPPYCA and its 5,3‐regioisomer and investigation of their thermal stability.
Franz, Florian; Angerer, Verena; Brandt, Simon D.; McLaughlin, Gavin; Kavanagh, Pierce V.; Moosman, Bjorn; Auwärter, Volker (Wiley, 2016-02)Recently, the pyrazole‐containing synthetic cannabinoid N‐(1‐amino‐3‐methyl‐1‐oxobutan‐2‐yl)‐1‐(cyclohexylmethyl)‐3‐(4‐fluorophenyl)‐1H‐pyrazole‐5‐carboxamide (3,5‐AB‐CHMFUPPYCA) has been identified as a ‘research chemical’ ... -
The synthesis and characterization of the ‘research chemical’ N-(1- amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl) -1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer.
Morris, Noreen; McLaughlin, Gavin; Kavanagh, Pierce V.; Power, John D.; Twamley, Brendan; O'Brien, John; Talbot, Brian; Dowling, Geraldine; Brandt, Simon D. (Wiley, 2016-09)This study presents the identification of N-(1-amino-3-methyl-1-oxobutan-2-yl)-1- (cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide that was termed 3,5-AB-CHMFUPPYCA. This compound was obtained from a ... -
Synthesis, analytical characterization and monoamine transporter activity of the new psychoactive substance 4- methylphenmetrazine (4-MPM), with differentiation from its ortho- and meta- positional isomers
McLaughlin, Gavin; Baumann, Michael H.; Kavanagh, Pierce V.; Morris, Noreen; Power, John D.; Dowling, Geraldine; Twamley, Brendan; O'Brien, John; Hessman, Gary; Westphal, Wolker; Walther, Donna; Brandt, Simon D. (Wiley, 2018-09)The availability of new psychoactive substances on the recreational drug market continues to create challenges for scientists in the forensic, clinical and toxicology fields. Phenmetrazine (3-methyl-2-phenylmorpholine) ... -
Synthesis, characterization and monoamine transporter activity of the new psychoactive substance 3’,4’-methylenedioxy-4-methylaminorex (MDMAR).
McLaughlin, Gavin; Morris, Noreen; Kavanagh, Pierce V.; Power, John D.; Twamley, Brendan; O'Brien, John; Talbot, Brian; Dowling, Geraldine; Mahony, Olivia; Brandt, Simon D.; Patrick, Julian; Archer, Roland P.; Partilla, John S.; Baumann, Michael H. (Wiley, 2015-07)The recent occurrence of deaths associated with the psychostimulant cis-4,4'-dimethylaminorex (4,4'-DMAR) in Europe indicated the presence of a newly emerged psychoactive substance on the market. Subsequently, the existence ... -
Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers
Morris, Noreen; McLaughlin, Gavin; Kavanagh, Pierce V.; Dowling, Geraldine; Power, John D.; Twamley, Brendan; O'Brien, John; Talbot, Brian; Sitte, Harald H.; Brandt, Simon D. (Wiley, 2017-03)The knowledge captured in patent and scientific research literature stimulates new ideas and fosters new drug development efforts. Manufacturers and entrepreneurs dedicated to the sale of ‘research chemicals’ and/or ...