Browsing Articles - Department of Pharmaceutical Sciences and Biotechnology by Title
Now showing items 10-29 of 43
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Detection, toxicology, environmental fate and risk assessment of nanoparticles in the aquatic environment (DeTER)
(EPA, 2018)Nanotechnology is an emerging technology that has the potential to impact on all aspects of life and the economy and is expected to form the basis of several technological innovations and advances in the 21st century. ... -
Determination of the effect of dairy powders on adherence of Streptococcus sobrinus and Streptococcus salivarius to hydroxylapatite and growth of these bacteria
(Elsevier, 2011-06-12)Dental caries is a highly prevalent disease caused by colonisation of tooth surfaces by cariogenic bacteria, such as Streptococcus sobrinus and Streptococcus salivarius. Reducing initial adherence of such bacteria to teeth ... -
DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.
(BMC, 2010-10-13)Background: Studies in mice and humans have shown that imprinted genes, whereby expression from one of the two parentally inherited alleles is attenuated or completely silenced, have a major effect on mammalian ... -
DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits
(BMC, 2011-01-11)Background: Genes which are epigenetically regulated via genomic imprinting can be potential targets for artificial selection during animal breeding. Indeed, imprinted loci have been shown to underlie some important ... -
Effectiveness of front line and emerging fungal disease prevention and control interventions and opportunities to address appropriate eco-sustainable solutions
(Elsevier, 2022-08-21)Fungal pathogens contribute to significant disease burden globally; however, the fact that fungi are eukaryotes has greatly complicated their role in fungal-mediated infections and alleviation. Antifungal drugs are often ... -
Fluorinated phenmetrazine “legal highs” act as substrates for high-affinity monoamine transporters of the SLC6 family.
(Elsevier, 2018-05-15)A variety of new psychoactive substances (NPS) are appearing in recreational drug markets worldwide. NPS are compounds that target various receptors and transporters in the central nervous system to achieve their ... -
In silico screening of phytochemicals from Dissotis rotundifolia against Plasmodium falciparum Dihydrofolate Reductase.
(Elsevier, 2023-04-01)Background: Malaria remains a major health concern in developing countries with high morbidity and mortality, especially in pregnant women and infants. A major obstacle to the treatment of malaria is a low effectiveness ... -
In vitro metabolism of the synthetic cannabinoid 3,5‐AB‐CHMFUPPYCA and its 5,3‐regioisomer and investigation of their thermal stability.
(Wiley, 2016-02)Recently, the pyrazole‐containing synthetic cannabinoid N‐(1‐amino‐3‐methyl‐1‐oxobutan‐2‐yl)‐1‐(cyclohexylmethyl)‐3‐(4‐fluorophenyl)‐1H‐pyrazole‐5‐carboxamide (3,5‐AB‐CHMFUPPYCA) has been identified as a ‘research chemical’ ... -
Influence of reconstitution temperature on survival of Cronobacter Sakazakii in powdered infant formula.
(Slovak University of Agriculture in Nitra. Faculty of Biotechnology and Food Sciences., 2016-04)Cronobacter spp. are emerging opportunistic pathogens commonly associated with the feeding of powdered infant formula (PIF). This study aimed to investigate the ability of C.sakazakii (ATCC 29544) to survive heat injury ... -
Insights into the mechanisms of Cronobacter sakazakii virulence
(Elsevier, 2022-06)Cronobacter species have adapted to survive harsh conditions, particularly in the food manufacture environment, and can cause life-threatening infections in susceptible hosts. These opportunistic pathogens employ a multitude ... -
Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecXG, FecXB) and GDF9 (FecGH) in Belclare and Cambridge sheep.
(PLOS, 2013-01)This paper concerns the likely origin of three mutations with large effects on ovulation rate identified in the Belclare and Cambridge sheep breeds; two in the BMP15 gene (FecXG and FecXB) and the third (FecGH) in GDF9. ... -
Investigations on the efficacy of routinely used phenotypic methods compared to genotypic approaches for the identification of staphylococcal species isolated from companion animals in Irish veterinary hospitals
(BMC, 2013)BACKGROUND: Identification of Staphylococci to species level in veterinary microbiology is important to inform therapeutic intervention and management. We report on the efficacy of three routinely used commercial phenotypic ... -
Isocractic LC methods for the trace analysis of phthalates and 4-nonylphenol in varying types of landfill and adjacent run-offs.
(Taylor & Francis Online, 2007-07)To determine the levels of known endocrine disrupting chemicals such as phthalates and alkylphenols in environmental samples such as leachate water and sediment, suitable isocratic high performance liquid chromatographic ... -
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
(Elsevier, 2010-02-01)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer’s Disease (AD). They are stable in human plasma but in mouse plasma they ... -
A laboratory investigation of the antimicrobial activity of a selection of western phytomedicinal tinctures.
(Elsevier, 2018-04)Introduction: Following the observed success of a herbal cocktail in controlling and eliminating acute respiratory infections in a group of approximately sixty, 1–3 year old equines, it was decided to test ten of the herbs ... -
Microbiological degradation of pesticides in yard waste composting.
(American Society for Microbiology, 1991)Changes in public opinion and legislation have led to the general recognition that solid waste treatment practices must be changed. Solid-waste disposal by landfill is becoming increasingly expensive and regulated and no ... -
Natural and synthetic isothiocyanates possess anticancer potential against liver and prostate cancer in vitro.
(International Institute of Anticancer Research, 2019-07)Background/Aim: Isothiocyanates (ITCs) are phytochemicals with potential cancer-preventative properties derived from the breakdown of glucosinolates that exist in cruciferous vegetables. Studies, to date, have ... -
A note on the use of FTA™ technology for storage of blood samples for DNA analysis and removal of PCR inhibitors
(Sciendo, 2009-01)FTA™ technology is widely used across many molecular disciplines for sample capture, storage and analysis. The use of this technology for the long-term storage of blood samples for DNA analysis was examined as well as ... -
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase.
(Elsevier, 2008-09-25)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ... -
Polymorphism discovery and allele frequency estimation using high-throughput DNA sequencing of target-enriched pooled DNA samples
(BMC, 2012-01-11)Background: The central role of the somatotrophic axis in animal post-natal growth, development and fertility is well established. Therefore, the identification of genetic variants affecting quantitative traits within ...