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Synthesis, characterization and monoamine transporter activity of the new psychoactive substance 3’,4’-methylenedioxy-4-methylaminorex (MDMAR).

McLaughlin, Gavin; Morris, Noreen; Kavanagh, Pierce V.; Power, John D.; Twamley, Brendan; O'Brien, John; Talbot, Brian; Dowling, Geraldine; Mahony, Olivia; Brandt, Simon D.; Patrick, Julian; Archer, Roland P.; Partilla, John S.; Baumann, Michael H. (Wiley, 2015-07)

The recent occurrence of deaths associated with the psychostimulant cis-4,4'-dimethylaminorex (4,4'-DMAR) in Europe indicated the presence of a newly emerged psychoactive substance on the market. Subsequently, the existence ...

Test purchase, synthesis and characterization of 2- methoxydiphenidine (MXP) and differentiation from its metaand para-substituted isomers.

Morris, Noreen; McLaughlin, Gavin; Kavanagh, Pierce V.; Power, John D.; O'Brien, John; Talbot, Brian; Elliott, Simon P.; Wallach, Jason; Hoang, Khoa; Morris, Hamilton; Brandt, Simon D. (Wiley, 2015-09)

The structurally diverse nature of the 1,2-diphenylethylamine template provides access to a range of substances for drug discovery work but some have attracted attention as ‘research chemicals’. The most recent examples ...

The synthesis and characterization of the ‘research chemical’ N-(1- amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl) -1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer.

Morris, Noreen; McLaughlin, Gavin; Kavanagh, Pierce V.; Power, John D.; Twamley, Brendan; O'Brien, John; Talbot, Brian; Dowling, Geraldine; Brandt, Simon D. (Wiley, 2016-09)

This study presents the identification of N-(1-amino-3-methyl-1-oxobutan-2-yl)-1- (cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide that was termed 3,5-AB-CHMFUPPYCA. This compound was obtained from a ...

Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers

Morris, Noreen; McLaughlin, Gavin; Kavanagh, Pierce V.; Dowling, Geraldine; Power, John D.; Twamley, Brendan; O'Brien, John; Talbot, Brian; Sitte, Harald H.; Brandt, Simon D. (Wiley, 2017-03)

The knowledge captured in patent and scientific research literature stimulates new ideas and fosters new drug development efforts. Manufacturers and entrepreneurs dedicated to the sale of ‘research chemicals’ and/or ...

Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone.

Morris, Noreen; McLaughlin, Gavin; Kavanagh, Pierce V.; Power, John D.; Twamley, Brendan; O'Brien, John; Talbot, Brian; Dowling, Geraldine; Mahony, Olivia; Brandt, Julian; Archer, Roland P.; Partilla, John S.; Baumann, Michael H. (Wiley, 2017-03)

3-Methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one (mexedrone) appeared in 2015 and was advertised by UK Internet retailers as a noncontrolled mephedrone derivative (2-(methylamino)-1-(4- methylphenyl)propan-1-one), ...

Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para- substituted isomers. [Poster]

McLaughlin, Gavin; Morris, Noreen; Kavanagh, Pierce V.; Dowling, Geraldine; Power, John D.; Twamley, Brendan; O'Brien, John; Talbot, Brian; Sitte, Harald H.; Brandt, Simon D. (2016)