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Processing stability and the significance of variation in extrusion speeds and temperture on SSB® 55 Pharma Grade Shellac for Oral Drug Delivery
(MDPI, 2017-09-06)
The melt-extrusion process is utilized in the pharmaceutical arena for the manufacturing of a variety of dosage forms and formulations, including solid dispersions. This technology is considered an efficient and continuous ...
Preclinical assessment of biomimetic and bioactive bone regeneration scaffold in femoral condyle defect of Sprague Dawley rats.
(Athlone Institute of Technology, 2020)
A fabricated biomimetic bone scaffold, incorporating osteogenic factors, presents a promising alternative to traditional autologous and
allogeneic bone fracture treatments. Here, the principles of biology and engineering ...
Material considerations for fused-filament fabrication of solid dosage forms.
(MDPI, 2018-04-02)
Material choice is a fundamental consideration when it comes to designing a solid dosage form. The matrix material will ultimately determine the rate of drug release since the physical properties (solubility, viscosity, ...
An investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed Copovidone hot-melt extruded solid dispersions.
(Elsevier, 2019-10)
Previous research has focused on spray dried quaternary mixtures which due to the addition of a surfactant 26 affected the physical stability and amorphous stability of selected model drugs. Very little research has 27 ...
Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model.
(Wiley Online Library, 2019-08-08)
Scaffolds are models designed to aid the interaction between cells and extracellular bone matrix, providing structural support for newly formed bone tissue. In this work, wollastonite with β‐TCP porous ceramic scaffolds ...
Development of novel polyethylene glycol dimethacrylate (PEGDMA)-based hydrogels for never regeneration
(Athlone Institute of Technology, 2020-06)
Injury to the peripheral nervous system (PNS) affects more than 1,000,000 people worlwide a year. It is estimated that $150 billion is spent on nerve injury repair in the USA alone each year. The current surgical methods ...
3D printed polymers are less stable than injection moulded counterparts when exposed to terminal sterilization processes using novel vaporized hydrogen peroxide and electron beam processes.
(Elsevier, 2019-11-21)
There is an increasing trend for use of 3D printing processes in healthcare due in part to emergence of customised medical devices and associated low manufacturing cost. However, there is a dearth of knowledge on the ...
Additive manufacturing of personalized pharmaceutical dosage forms via stereolithography.
(MDPI, 2019-12-03)
The introduction of three-dimensional printing (3DP) has created exciting possibilities for
the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage
forms of two drug ...
Development of a new bone scaffold for the treatment of large bone defects
(Athlone Institute of Technology, 2020-06)
Large bone defects
are typically caused by incidents
such
as fractures, diseases, trauma or surgeries. Worldwide more that 3/5 million bone grafts (either autografts or allografts) are performed each year.
Smart hydrogels: therapeutic advancements in hydrogel technology for smart drug delivery applications.
(Wiley, 2015-12)
Hydrogels are a fusion of solid and liquid phases which closely mimic biological tissue. As such they have enormous potential for drug delivery systems as they are biocompatible and may be tailored to specific applications. ...