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Modification of hyaluronic acid for stereolithography 3D printing of hydrogel nerve conduits
(Athlone Institute of Technology, 2020-06)
The peripheral nervous system transmits signals from the brain to the limbs and organs of the
body. Peripheral nerve injuries (PNIs) resulting from trauma, illness or cancer affect
approximately 1 million people in Europe ...
β-glucan metabolic and immunomodulatory properties and potential for clinical application
(MDPI, 2020-12-10)
β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties. β-glucans have metabolic and gastro-intestinal effects, ...
β-Glucan
(MDPI, 2021)
β-glucans are a key active ingredient in mushrooms and are also found in oats, barley, yeast, bacteria and algae. In microbial sources, they are a structural component and in grain sources, they are found in the endospermic ...
An investigation into the effect of hyaluronic acid (HLA) polymer size on neuronal and glial cell viability and attachment
(Athlone Institute of Technology, 2019-06)
HLA is a human endogenous biopolysaccharide discovered by Karl Meyer in 1938, in the vitreous
humour of bovine eyes and is a key component of the extracellular matrix (ECM) found in every cell
type in the body. It is ...
Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions
(Elsevier, 2022-02-25)
Acute respiratory distress syndrome (ARDS) is the most common form of acute severe hypoxemic respiratory failure in the critically ill with a hospital mortality of 40%. Alveolar inflammation is one of the hallmarks for ...
Purified β‐glucans from the Shiitake mushroom ameliorates antibiotic‐resistant Klebsiella pneumoniae‐induced pulmonary sepsis
(Society for Applied Microbiology, 2020-07-24)
Bacterial infection remains the main cause of acute respiratory distress syndrome and is a leading cause of death and disability in critically ill patients. Here we report on the use of purified β‐glucan (lentinan) extracts ...
β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects — Implications for coronavirus disease (COVID-19) immunotherapies.
(Elsevier, 2020-05-11)
Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute respiratory distress syndrome (ARDS) and death. ...