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    β-glucan metabolic and immunomodulatory properties and potential for clinical application 

    Murphy, Emma J.; Rezoagli, Emanuele; Major, Ian; Rowan, Neil J.; Laffey, John G. (MDPI, 2020-12-10)
    β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties. β-glucans have metabolic and gastro-intestinal effects, ...
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    β-Glucan 

    Murphy, Emma J.; Rezoagli, Emanuele; Major, Ian; Rowan, Neil J.; Laffey, John (MDPI, 2021)
    β-glucans are a key active ingredient in mushrooms and are also found in oats, barley, yeast, bacteria and algae. In microbial sources, they are a structural component and in grain sources, they are found in the endospermic ...
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    Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions 

    Murphy, Emma J.; Rezoagli, Emanuele; Pogue, Robert; Simonassi-Paiva, Bianca; Abidin, Ismin Izwani Zainol; Fehrenbach, Gustavo Waltzer; O'Neil, Emer; Major, Ian; Laffey, John G.; Rowan, Neil J. (Elsevier, 2022-02-25)
    Acute respiratory distress syndrome (ARDS) is the most common form of acute severe hypoxemic respiratory failure in the critically ill with a hospital mortality of 40%. Alveolar inflammation is one of the hallmarks for ...
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    Mucoadhesive bilayer vaginal tablet as a potential treatment for cervical cancer 

    Abidin, Ismin Izwani Zainol; Murphy, Emma J.; Rezoagli, Emanuele; Major, Ian (Athlone Institute of Technology, 2020-06)
    Cervical cancer is a cancer of the cells of the cervice. It is the 2nd most common cancer affecting women. >270,000 die from it annually. >5000,000 women worldwide are diagnosed.
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    A bilayer vaginal tablet for the localized delivery of disulfiram and 5-fluorouracil to the cervix 

    Abidin, Ismin Zainol; Rezoagli, Emanuele; Simonassi-Paiva, Bianca; Fehrenbach, Gustavo Waltzer; Masterson, Kevin; Pogue, Robert; Cao, Zhi; Rowan, Neil; Murphy, Emma J.; Major, Ian (MDPI, 2020-12-06)
    This study was performed to develop an adjuvant therapy in the form of a self-administered vaginal tablet regimen for the localized delivery of chemotherapeutic drugs. This therapy will help to reduce relapse by eradicating ...
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    β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects — Implications for coronavirus disease (COVID-19) immunotherapies. 

    Murpyhy, Emma J.; Masterson, Claire; Rezoagli, Emanuele; O'Toole, Daniel; Major, Ian; Stack, Gary D.; Lynch, Mark; Laffey, John G.; Rowan, Neil J. (Elsevier, 2020-05-11)
    Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute respiratory distress syndrome (ARDS) and death. ...
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    A systematic review of mucoadhesive vaginal tablet testing 

    Abidin, Ismin Zainol; Murphy, Emma J.; Fehrenvbach, Gustavo Waltzer; Rezoagli, Emanuele; Gately, Noel; Major, Ian (AboutScience, 2023-01-16)
    Drug administration through the vaginal tract is one of the oldest modalities of pharmacotherapy, and it is also one of the most explored. Since the vaginal cavity has a wide surface area, a plentiful blood supply, and a ...

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    Major, Ian (7)
    Rezoagli, Emanuele (7)
    Murphy, Emma J. (6)Rowan, Neil J. (4)Laffey, John G. (3)Abidin, Ismin Izwani Zainol (2)Abidin, Ismin Zainol (2)Fehrenbach, Gustavo Waltzer (2)Pogue, Robert (2)Simonassi-Paiva, Bianca (2)... View MoreSubjectBioscience Research Institute AIT (4)Cervical cancer (2)Immunomodulation (2)Vaginal drug delivery (2)β-Glucans (2)ARDS (1)Bilayer tablets (1)Biomedicine (1)Chitosan (1)Clinical trials (1)... View MoreDate Issued2020 (4)2021 (1)2022 (1)2023 (1)Has File(s)
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