Although hydrogels produced via freeze-thawing (F/T) technique have been thoroughly studied in literature, stretching hydrogels in between freeze-thawing cycles could change its properties and might be modulated for drug ...

Electrospinning is one of the foremost nanotechnology applications to fabricate bone tissue engineering scaffolds with sizes in the nanometer range. It is regarded as a versatile, inexpensive, and relatively simple methodology ...

Although freeze-thaw mechanism for producing crosslinked hydrogels is relatively easy and simple, it lacks sufficient integrity and support leading to modifications on its three-dimensional polymeric network arrangement ...